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Breast perfusion preparation for treating mammitis of milk cow in lactation period and preparation method thereof

A technology for dairy cow mastitis and perfusion agent, which is applied to medical preparations, pharmaceutical formulations, organic active ingredients and other directions containing active ingredients, can solve the problems of high price, easy decomposition and instability of clavulanic acid, and achieves high popularization and application. The effect of value, good stability and low production cost

Inactive Publication Date: 2009-11-18
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes how it can be applied to prevent or reduce inflammations that occur from dairy cows' use of certain drugs called antibiotics. These agents help fight against other diseases like colds but they also work with them effectively when combined together. They combine two types of medicine - one being specific type of drug while another containing pregnant liquor injection solution mixed into each ingredient separately. By combining these different components, this new formulation becomes more effective than just simply mixing all their active ingredients alone without adding any extra substances such as water. Additionally, its stable properties make it easier to store overtime and manufacture costs are lower compared to existing methods.

Problems solved by technology

This patents discusses different ways that current methods for managing milkfections may be costly and require high levels of effort during administration compared to new therapy options like anti-microbial medication (AMI).

Method used

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  • Breast perfusion preparation for treating mammitis of milk cow in lactation period and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1, the preparation of the udder perfusion agent for the treatment of lactating dairy cow mastitis

[0041] The formula of the udder perfusion agent for the treatment of lactating dairy cow mastitis of the present invention is as follows:

[0042] Matrix:

[0043] Hydrogenated Castor Oil 1.00g

[0044] Tween-80 0.10g

[0045] Propyl gallate 0.02g

[0046] Benzyl alcohol 0.10g

[0047] Soybean oil for injection 98.78g

[0048] Total 100.00g

[0049] Active ingredient content per 3g formula:

[0050] Amoxicillin 200mg

[0051] Sulbactam 50mg

[0052] Prednisolone 10mg

[0053] The preparation method of the udder perfusion agent for the treatment of lactating dairy cow mastitis provided by the present invention comprises the following steps:

[0054] (1) Dissolve hydrogenated castor oil and propyl gallate in an appropriate amount of soybean oil for hot injection in the prescribed amount, and after all of them have been dissolved, add benzyl alcohol and ...

Embodiment 2

[0059] Embodiment 2, the preparation of the udder perfusion agent for the treatment of lactating dairy cow mastitis

[0060] The formula of the udder perfusion agent for the treatment of lactating dairy cow mastitis of the present invention is as follows:

[0061] Matrix:

[0062] Hydrogenated Castor Oil 0.50g

[0063] Sodium carboxymethylcellulose 0.50g

[0064] Span-80 0.05g

[0065] Ethylene oxide-40-hydrogenated castor oil 0.05g

[0066] Propyl gallate 0.01g

[0067] Thiourea 0.01g

[0068] Benzyl alcohol 0.05g

[0069] Propylparaben 0.05g

[0070] Soybean oil for injection 49.39g

[0071] Castor Oil for Injection 49.39g

[0072] Total 100g.00

[0073] Active ingredient content per 3g formula:

[0074] Amoxicillin 250mg

[0075] Sulbactam 100mg

[0076] Prednisolone 5mg

[0077] The preparation method of the udder perfusion agent for the treatment of lactating dairy cow mastitis provided by the present invention comprises the following steps:

[0078] (1) Di...

Embodiment 3

[0082] Embodiment 3, the preparation of the udder perfusion agent for the treatment of lactating dairy cow mastitis

[0083] The formula of the udder perfusion agent for the treatment of lactating dairy cow mastitis of the present invention is as follows:

[0084] Matrix:

[0085] Xanthan Gum 1.20g

[0086] Span-60 0.50g

[0087] Vitamin E 0.05g

[0088] Methylparaben 0.05g

[0089] Lecithin 0.20g

[0090] Ethyl oleate 98.00g

[0091] Total 100.00g

[0092] Active ingredient content per 3g formula:

[0093] Amoxicillin 150mg

[0094] Sulbactam 125mg

[0095] Prednisolone 15mg

[0096] The preparation method of the udder perfusion agent for the treatment of lactating dairy cow mastitis provided by the present invention comprises the following steps:

[0097] (1) Dissolve xanthan gum, vitamin E, methylparaben, and lecithin in an appropriate amount of hot ethyl oleate in the prescribed amount, and after all of them are dissolved, add Span-60 in the prescribed amount to...

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Abstract

The invention provides a breast perfusion preparation for treating mammitis of milk cow in lactation period, which belongs to the field of medical preparation for veterinary use; every 3g of the perfusion preparation contains 150-250 mg of amoxicillin, 50-125 mg of sulbactam, 5-15 mg of prednisolone and the rest of substrate; the substrate contains 0.1-12% of suspending aid, 0.1-2% of wetting agent, 0.01-1% of antioxidant, 0.05-1% of preservative and the rest of dispersion medium; the invention can be obtained via the following steps: firstly, dissolving or dispersing suspending aid, antioxidant, wetting agent and preservative into proper amount of dispersion medium, then slowly adding the rest of the dispersion medium into a colloid mill to obtain the substrate, adding medicine into the substrate, grinding via the alternating method of circularly grinding and non-circularly grinding. The preparation of the invention is simple in preparation technique, easy to realize industrialization, low in production cost, low in expenditure for treatment, low in toxicity, wide to use and high in efficiency; the invention can be clinically used for treating mammitis in lactation period caused by Gram positive bacterium and Gram negative bacterium.

Description

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Claims

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Application Information

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Owner CHINA AGRI UNIV
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