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Quick detection method for nafil type PDE-5 inhibitor in Chinese patent drug, health food and foods

A technology of health food and detection method, which is applied in the direction of chemical analysis by precipitation, which can solve the problems of limited application range and achieve the effect of low analysis cost, strong specificity and high sensitivity

Inactive Publication Date: 2009-11-25
广东省药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the scope of application of this patent is limited to the detection of sildenafil citrate, and the scope of application is limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Nafil class PDE added in a kind of medicine, health food and food of the present invention 5 The rapid detection method of type inhibitor, comprises the steps:

[0021] 1. Preparation of test solution

[0022] Take 1 capsule (approximately 1 / 2 tablet; about 1 / 10 of the dosage of solid preparations such as pills, granules, powders, etc.; 2ml of solution), and put it in a stoppered test tube (tablets and pills need to be prepared in advance). Finely grind or chop), add 20ml of 1% sulfuric acid solution, shake vigorously for about 2 minutes to dissolve, let stand for a while, and filter.

[0023] In another embodiment, the sulfuric acid solution has a concentration of 20% by weight, and 1 ml is added.

[0024] In another embodiment, the sulfuric acid solution has a concentration of 10% by weight, and 5ml is added.

[0025] 2. Eliminate interfering substances

[0026]Take 2ml of the continued filtrate, add 0.04mol / L potassium permanganate solution dropwise, shake while ...

Embodiment 2

[0038] With the Nafil class PDE added in the medicine of the present invention, health food and food 5 A rapid detection method for type inhibitors detects the test product 1 # .

[0039] Test product 1 # : Labeled as Sea Dog King Capsules, batch number 20080716, take 1 capsule each time.

[0040] Take 1 capsule, put it in a stoppered test tube, add 8ml of sulfuric acid solution with a concentration of 3% by weight, shake vigorously for about 2 minutes to dissolve, let stand for a while, and filter. Take 2ml of continued filtrate, add 0.04mol / L potassium permanganate solution dropwise, shake while adding dropwise, until the purple-red color that appears in the solution does not fade within 15 seconds, let it stand for 1 minute, add saturated solution of trinitrophenol dropwise 4 drops, the solution immediately has a yellow insoluble precipitate and becomes turbid, thus judging that the sample contains Nafil PDE 5 type inhibitors.

[0041] It was detected by high-performan...

Embodiment 3

[0043] With the Nafil class PDE added in the medicine of the present invention, health food and food 5 The rapid detection method of type inhibitors detects the test product 2#.

[0044] Test product 2#: marked as Zhuang Tiangen Capsules, batch number 05.01.18, take 1 capsule each time.

[0045] Take 1 capsule, put it in a stoppered test tube, add 8ml of sulfuric acid solution with a concentration of 3% by weight, shake vigorously for about 2 minutes to dissolve, let stand for a while, and filter. Take 2ml of continued filtrate, add 0.04mol / L potassium permanganate solution dropwise, shake while adding dropwise, until the purple-red color that appears in the solution does not fade within 15 seconds, let it stand for 1 minute, add saturated solution of trinitrophenol dropwise 4 drops, the solution immediately has a yellow insoluble precipitate and becomes turbid, thus judging that the sample contains Nafil PDE 5 type inhibitors.

[0046] It was detected by high performance l...

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Abstract

This invention provides a quick detection method for nafil type PDE-5 inhibitor in Chinese patent drug, health food and foods, comprising selecting drug, health food or food, and adding in 1 to 20 ml sulfuric acid solution with a weight percentage of 1 to 20 percent; shaking to dissolve the solution; standing for a while; filtering; dropping 0.01 to 0.02 mol / L potassium permanganate solution in subsequent filtrate till mauve disappears in the solution and does not disappear in fifteen seconds; then dropping trinitrophenol saturated solution and observing whether there is yellow turbidity produced. This invention is applied to quick detection of all kinds of dosage forms of Chinese patent drugs, health foods and foods, with low analysis cost, simple operation, strong specificity, high sensitivity and high accuracy, without specific devices; this invention applied to quick screening on spot.

Description

technical field [0001] The invention relates to the technical field of analysis of Chinese patent medicine, health food or food, in particular to a rapid screening of Nafil PDE in Chinese patent medicine, health food or food based on physical and chemical reactions 5 methods for the detection of inhibitors. Background technique [0002] Illegal addition of chemical ingredients in Chinese patent medicines for nourishing kidney and strengthening yang, health food and food is becoming more and more rampant. Illegal addition of chemical ingredients is relatively common, and there are more and more high-tech counterfeiting activities aimed at standards, which seriously threaten the health of the people. After reviewing a large number of domestic and foreign literature, it was found that the illegally added aphrodisiac chemical ingredients are mainly PDE 5 Type inhibitor (phosphodiesterase type 5 inhibitor, phosphodiesterase type-5 inhibitor) is the main one. The U.S. Food and D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N31/02
Inventor 罗卓雅林生文赖宇红魏嘉陵李晨辉杨德忠雷毅李延志
Owner 广东省药品检验所
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