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Chinese medicinal composition for treating viral myocarditis and preparation process thereof

A technology for viral myocarditis and composition, applied in the field of traditional Chinese medicine composition, can solve the problems such as further clinical evaluation of curative effect, virus spread, lack of chest pain and the like

Active Publication Date: 2010-02-03
上海方心制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The functions of "replenishing qi and nourishing yin" or "reinforcing qi and yin" mentioned above are undoubtedly used to treat patients with both qi and yin deficiency. It can be seen that myocarditis is very common in patients with qi and yin deficiency. attention, and created many prescriptions and Chinese patent medicines, but considering that these prescriptions and Chinese patent medicines still have some shortcomings: if some prescriptions lack the consideration of improving chest pain, and some prescriptions lack the care of regulating arrhythmia, Some prescriptions use drugs that are not related to this disease
[0005] Hormone drugs commonly used clinically may cause the spread of the virus due to the suppression of the body's own immune function when used in the early stage of viral infection, which may aggravate the condition or cause the condition to rebound; Non-specific anti-virus, GIK treatment, etc. are just non-specific support or symptomatic treatment, and it is difficult to solve the problem from the root of the virus
In recent years, some traditional Chinese medicine compound preparations have been listed on the market, such as Yurong Yangxin Dan, etc., but their exact curative effects have yet to be further evaluated clinically; the Huangqi injection currently used in clinical practice is also reported to have certain curative effects, but it has no direct effect on viruses. The killing effect, the final effect needs to be evaluated

Method used

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  • Chinese medicinal composition for treating viral myocarditis and preparation process thereof
  • Chinese medicinal composition for treating viral myocarditis and preparation process thereof
  • Chinese medicinal composition for treating viral myocarditis and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0196] Astragalus 6.0kg, Sun-dried ginseng 2.4kg, Sophora flavescens 3.6kg, Salvia miltiorrhiza 4.8kg, Ophiopogon japonicus 4.8kg, the above medicinal materials total 21.6kg. After the medicinal materials were crushed, the Astragalus medicinal materials were taken, extracted twice with 70% ethanol under reflux, the first time adding 216kg for extraction for 1.5 hours, the second time adding 172.8kg for extraction for 1.0 hour, filtering, and the astragalus ethanol extract was placed separately. Astragalus extracted by ethanol, and other 4 medicinal materials, add water and decoct three times, add 259.2kg each time, decoct for 1.0 hour, filter; combine the filtrates, concentrate to a density of 1.10-1.15 (50°C), add 95 % ethanol to 65% alcohol content, refrigerated (about 4°C) for 12 hours, filtered, the filtrate was combined with the ethanol extract of Radix Astragali, concentrated under reduced pressure at 0.2mpa, 50°C, the concentrated solution was dried in a vacuum oven at 5...

example 2

[0198] Preparation of pilot test:

[0199] Prepare the granule of 6g / bag specification by the extract of example 1 method, production and inspection situation are as follows.

[0200] The amount of extract is 150g, mannitol 75g, aspartame 1.5g, mix well, 10% PVP90% ethanol solution is appropriate, granulated and dried to make granules, the filling capacity is 6g / bag, the output is 35 bags, and the yield is 94.6%. .

example 3

[0202] tablet:

[0203] 6 grams of raw sun-dried ginseng, 12 grams of salvia miltiorrhiza, 9 grams of sophora flavescens, 15 grams of raw astragalus, and 12 grams of Ophiopogon japonicus. Above-mentioned each Chinese medicine is made into extractum by example 1 method and pharmaceutical adjuvant, is made into tablet by tablet conventional method.

[0204] When taking, take 6 grams each time (2 grams per tablet), orally 3 times, and take it with warm boiled water.

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Abstract

The invention discloses a Chinese medicinal composition for treating viral myocarditis, which is prepared from the following Chinese medicinal raw materials in portion by weight: 0 to 10 portions of sun-dried ginseng, 1 to 15 portions of danshen root, 1 to 14 portions of lightyellow sophora root, 1 to 20 portions of radix astragali, and 1 to 18 portions of ophiopogon root. Animal experiments showthat the Chinese medicinal composition for treating the viral myocarditis has protection function on SD rat Coxsackie viral myocarditis and good protection function on the damage to the culturing of myocardial cells of the rat caused by doxorubicin, can be used for treating the viral myocarditis, and has great clinical value.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating viral myocarditis and a preparation process thereof. Background technique: [0002] With the development of medical technology, the diagnostic level of viral myocarditis has made great progress. In recent years, the reported incidence of the disease has increased, but there is still no major progress in treatment. [0003] According to relevant medical monographs (edited by Yu Xiangdong: "Myocarditis". China Traditional Chinese Medicine Press, 2005, P.3.): "Myocarditis refers to the localized or diffuse inflammation of myocardial cells and their tissue spaces, It can originate in the myocardium, or it can be caused by systemic diseases involving the myocardium." Based on different etiologies, myocarditis can be divided into infectious myocarditis such as viruses and bacteria, myocarditis caused by allergies, all...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/20A61K9/10A61K9/48A61K9/08A61P9/00A61P31/12
Inventor 张昕张鼎樑谢利宁蔡素琴张坚
Owner 上海方心制药科技有限公司
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