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Antitubercular injection and preparation method thereof

A technology for injection and tuberculosis, which is applied in the field of drug injection for treating tuberculosis and its preparation, can solve the problems of poor quality stability of traditional Chinese medicine injections and many side effects in clinical application, achieve remarkable curative effect, promote the recovery of human body's righteousness, and improve defense function defects Effect

Active Publication Date: 2010-03-10
张瑛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The object of the present invention is to, aiming at the shortcomings of the existing anti-tuberculosis drugs, overcome the technical defects of preparations such as poor quality stability of traditional Chinese medicine injections and many side effects in clinical application, and provide a drug for the treatment of various tuberculosis such as bone and joint tuberculosis, lymphatic tuberculosis, and pulmonary tuberculosis. and medicines and preparations for diseases such as neoplastic leprosy

Method used

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  • Antitubercular injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0057] Components and their proportions: Panax notoginseng 80g, astragalus 120g, drynaria drynaria 80g, frankincense (made) 120g, myrrh (made) 80g

[0058] Excipients and their proportions: 50g of glucose for injection, 20ml of polysorbate 80, 20ml of benzyl alcohol (unit: g ml)

[0059] Preparation:

[0060] 1. Take the coarse powder of notoginseng and extract it twice with purified water under reflux, filter for 1 hour each time, and filter the filtrate for later use; add astragalus membranaceus and Drynaria rhizome powder to the dregs, add purified water to decoct twice, 1 hour each time, filter , the filtrate and the Panax notoginseng filtrate were combined and concentrated to a relative density of 1.10-1.15 (40-50°C) to obtain a water-extracted concentrate.

[0061] 2. Add 3 times the amount of 95% ethanol to the water extraction concentrate prepared in 1, mix well, and let stand for 24 hours. Centrifuge, recover ethanol from the supernatant, add 2 times the amount of 9...

Embodiment approach 2

[0068] Components and their proportions: Sanqi 120g, Astragalus 80g, Drynaria drynaria 120g, Frankincense (made) 80g, Myrrh (made) 120g

[0069] Excipients and their proportions: 50g of glucose for injection, 20ml of polysorbate 80, 20ml of benzyl alcohol (unit: g ml)

[0070] Preparation:

[0071] 1. Take the coarse powder of notoginseng and extract it twice with purified water, 2 hours each time, filter, and use the filtrate for later use; add astragalus membranaceus and Drynaria rhizome powder to the dregs, add purified water to decoct twice, 2 hours each time, filter , the filtrate was combined with the Panax notoginseng filtrate, and concentrated to a relative density of 1.10-1.15 (45°C) to obtain a water-extracted concentrate.

[0072] 2. Add 2 times the amount of 95% ethanol to the water extraction concentrate prepared in 1, mix well, and let stand for 24 hours. Centrifuge, recover ethanol from the supernatant, add 3 times the amount of 95% ethanol, mix well, and let ...

Embodiment approach 3

[0079] Components and their proportions: Panax notoginseng 100g, astragalus 100g, drynaria drynaria 100g frankincense (made) 100g, myrrh (made) 100g

[0080] Excipients and their proportions: 50g of glucose for injection, 20ml of polysorbate 80, 20ml of benzyl alcohol (unit: g ml)

[0081] Preparation:

[0082] 1. Take the coarse powder of notoginseng and extract it twice with purified water, 2 hours each time, filter, and use the filtrate for later use; add astragalus membranaceus and rhizoma drynaria powder to the dregs, add purified water to decoct twice, 1 hour each time, filter , the filtrate was combined with the Panax notoginseng filtrate, and concentrated to a relative density of 1.10-1.15 (45°C) to obtain a water-extracted concentrate.

[0083] 2. Add 2 times the amount of 95% ethanol to the water extraction concentrate prepared in 1, mix well, and let stand for 48 hours. Centrifuge, recover ethanol from the supernatant, add 3 times the amount of 95% ethanol, mix we...

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Abstract

The invention relates to an antitubercular injection and a preparation method thereof. The antitubercular injection comprises the following traditional Chinese medicinal materials: panax notoginseng,astragalus, drynaria, olibanum and myrrh as well as glucose containing auxiliary materials for injection, polysorbate and benzyl alcohol and is prepared by the following process steps: preparing a concentrated solution, centrifugally separating, heating, dissolving, finely filtering, and the like. The invention solves the technical problems of unstable product quality and great clinical side effect caused by low production efficiency, poor medicinal liquid clarity, overstandard endotoxin, and the like due to easy membrane block and penetration in the production process of the traditional Chinese medicinal injection. The antitubercular injection has the functions of supplementing qi, nourishing the blood, tonifying the kidney, strengthening the bones and promoting blood circulation by removing blood stasis and is suitable for various tuberculosis, such as pulmonary tuberculosis, osteoarticular tuberculosis, lymphatic tuberculosis, and the like as well as nodular leprosy and other diseases.

Description

technical field [0001] The invention relates to a drug injection for treating tuberculosis and a preparation method thereof. Background technique [0002] According to data reports, since the 1990s, tuberculosis has begun to resurgence and spread throughout the world. The incidence rate continues to increase. At present, there are about 20 million tuberculosis patients in the world, and the new cases show an obvious upward trend. The number was 8 million in 1997, 8.4 million in 1999, and reached 11 million in 2005. [0003] my country is the main victim of tuberculosis in the world. The number of tuberculosis patients ranks second in the world, with about 2 million new cases and 150,000 deaths per year. It is one of the 22 countries with the highest burden of tuberculosis in the world. [0004] The anti-tuberculosis drugs currently used in clinical first-line mainly include chemical drugs such as rifampicin, isoniazid, pyrazinamide, ethambutol, and streptomycin. [0005] ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/08A61K47/34A61P31/06A61K47/10A61K47/26
Inventor 张瑛
Owner 张瑛
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