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Violet light pellet and preparation method thereof

A technology of micropills and purple salvia, applied in the field of Zideng micropills and its preparation, can solve the problems of small drug loading and limited development

Inactive Publication Date: 2011-08-17
北京化药科创医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Micropills are a dosage form with many advantages. For example, a dose is composed of multiple dispersed units. After oral administration, it can be dispersed in a large area and evenly in the gastrointestinal tract, which improves the bioavailability of the drug. The transport in the gastrointestinal tract is not affected. The impact of gastric emptying, the absorption reproducibility is good; however, there are many problems in the preparation of traditional Chinese medicine into pellets, especially for some preparations with large amount of Chinese medicine extract and containing directly crushed medicinal materials, due to the large amount of extract , high viscosity, when made into pellets, the development of traditional Chinese medicine extract pellets is usually limited due to the small drug loading

Method used

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  • Violet light pellet and preparation method thereof
  • Violet light pellet and preparation method thereof
  • Violet light pellet and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] prescription:

[0020] Purple Salvia 450g, Erigeron breviscapus 450g, Panax notoginseng 200g, Pueraria 200g, Licorice 100g

[0021] Microcrystalline cellulose 52g, micropowder silica gel 8g

[0022] Weigh the prescribed amount of Salvia Miltiorrhiza, Erigeron breviscapus, Panax notoginseng, Pueraria lobata, and licorice, and grind them into coarse powders, combine and mix well, and extract the combined powders with 10 times the amount of 60% ethanol for 3 times, each time for 2 hours , filter, merge the filtrate, the filtrate is concentrated under reduced pressure to a relative density of about 1.15, add ethanol to make the alcohol content of the concentrated medicinal solution 60%, stir well, leave it at room temperature for 12 hours, filter, and the filtrate is for subsequent use, and the filter residue is mixed with 60% ethanol Flow washing, combine the filter residue washing liquid with the filtrate, concentrate under reduced pressure until there is no alcohol smel...

Embodiment 2

[0025] prescription:

[0026] Purple Salvia 500g, Erigeron breviscapus 500g, Panax notoginseng 100g, Pueraria 100g, Licorice 50g

[0027] Microcrystalline cellulose 48g, micropowder silica gel 12g

[0028] Weigh the prescribed amount of Salvia Miltiorrhiza, Erigeron breviscapus, Panax notoginseng, Pueraria lobata, and licorice, and grind them into coarse powders, combine and mix, and extract the combined powders with 10 times the amount of 80% ethanol for 3 times, each time for 2 hours , filter, combine the filtrates, concentrate the filtrate under reduced pressure to a relative density of about 1.10, add ethanol so that the alcohol content of the concentrated medicinal solution is 70%, stir evenly, let stand at room temperature for 12 hours, filter, and the filtrate is for subsequent use, and the filter residue is mixed with 70% ethanol Flow washing, combine the filter residue washing liquid with the filtrate, concentrate under reduced pressure until there is no alcohol smel...

Embodiment 3

[0031] prescription:

[0032] Purple Salvia 300g, Erigeron breviscapus 300g, Panax notoginseng 300g, Pueraria 300g, Licorice 150g

[0033] Microcrystalline cellulose 66g, micropowder silica gel 10g

[0034] Weigh the prescribed amount of Salvia Miltiorrhiza, Erigeron breviscapus, Panax notoginseng, Pueraria lobata, and licorice, and grind them into coarse powders, combine and mix well, and extract the combined powders with 10 times the amount of 50% ethanol for 3 times, each time for 2 hours , filter, combine the filtrate, the filtrate is concentrated under reduced pressure to a relative density of about 1.20, add ethanol to make the alcohol content of the concentrated medicinal solution 50%, stir evenly, leave it at room temperature for 12 hours, filter, and the filtrate is for subsequent use, and the filter residue is mixed with 50% ethanol Flow washing, combine the filter residue washing liquid with the filtrate, concentrate under reduced pressure until there is no alcohol...

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Abstract

The invention relates to a violet light pellet and a preparation method thereof. The violet light pellet is prepared by extracting refined effective components of crude drug erigeron breviscapus, salvia przewalskii, pseudo-ginseng, the root of kudzu vine and liquoric root. Compared with the existing formulation of violet light capsule, the pellets have higher content of the effective components and more rapid medicine release speed in the human body.

Description

technical field [0001] The invention relates to purple lamp pellets and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Zideng Capsule is a compound preparation developed by Chuxiong Yi Autonomous Prefecture Traditional Chinese Medicine Hospital based on the prescription of Yi medicine monographs, using locally produced purple salvia miltiorrhiza, breviscapine, notoginseng, kudzu root, and licorice. , replenishing qi and activating blood circulation, relieving spasm and relieving pain, used for the treatment of cervical spondylosis. Zideng capsules are 0.5g per capsule, 4 capsules each time, 3 times a day, and the daily dosage is large. [0003] Micropills are a dosage form with many advantages. For example, a dose is composed of multiple dispersed units. After oral administration, it can be dispersed in a large area and evenly in the gastrointestinal tract, which improves the bioavailability o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16
Inventor 关屹闫冬
Owner 北京化药科创医药科技发展有限公司
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