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Polygala japonica fermenting oral liquid with anti-bacterial and anti-inflammatory activity and preparation method thereof

A technology for fermenting oral liquid and melon seed gold, which is applied in the field of preparation of fermented melon seed golden products to achieve the effect of no toxic and side effects

Inactive Publication Date: 2011-06-15
WUHAN MAIDESEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the research on the fermentation of melon seeds and the oral liquid prepared after fermentation. The present invention reports that the oral liquid prepared after the fermentation of melon seeds has obvious antibacterial and anti-inflammatory effects

Method used

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  • Polygala japonica fermenting oral liquid with anti-bacterial and anti-inflammatory activity and preparation method thereof
  • Polygala japonica fermenting oral liquid with anti-bacterial and anti-inflammatory activity and preparation method thereof
  • Polygala japonica fermenting oral liquid with anti-bacterial and anti-inflammatory activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the preparation of golden melon seed fermented extract

[0022] (1) Pretreatment of the melon seed gold: wash the melon seed gold, dry it at below 60°C for 12 hours, and pulverize it into powder after drying completely, and set it aside.

[0023] (2) Pretreatment of glutinous rice: After the glutinous rice is screened and cleaned, it is steamed by conventional methods, such as soaking with a sufficient amount of clean water for 8-10 hours, removing and draining, and steaming in a basket until it is cooked and not mushy, and the rice grains are plump and When the sandwich and granules are separated, when it is soft, elastic and not sticky to the hands, take it out immediately and rinse with cold boiled water to 35°C, let it stand until there is no large amount of water filtered out, and set aside.

[0024] (3) Preparation of Melon Seed Gold Fermentation Medium: a medium consisting of the following raw materials in parts by weight:

[0025] Guazijin 70

[...

Embodiment 2

[0030] Example 2: Preparation of Melon Seed Gold Fermented Oral Liquid

[0031] (1) The above-mentioned melon seed gold fermented extract and distilled water are mixed according to the ratio of 1:5, and 6% xylitol is added simultaneously to make an oral liquid, and the existing technology is used to divide and pack into bottles, and after disinfection and sterilization, it is prepared in 4 ℃ refrigerator.

[0032] (2) The above-mentioned melon seed gold fermented extract and distilled water are mixed according to the ratio of 1:6, and 6% xylitol is added simultaneously to make an oral liquid, and the existing technology is used to divide into bottles, and after disinfection and sterilization, Store in refrigerator at 4°C.

[0033] (3) Mix the above-mentioned melon seed gold fermented extract with distilled water according to the ratio of 1:7, add 6% xylitol at the same time to make oral liquid, utilize existing technology to divide into bottles, after sterilization and Store...

Embodiment 3

[0034] Embodiment 3: Antibacterial test in vitro of fermented melon seed gold preparation

[0035] (1) Selection of strains: Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas.

[0036] (2) Agar plate diffusion method (filter paper method) was used to measure the in vitro antibacterial activity of the melon seed gold fermented preparation in the above example 2: the bacterial classification cultivated at 37°C for 24h was mixed with sterilized physiological saline, so that the bacterial content reached 10 5 cfu / ml. Use a micro-sampler to take 0.1ml of bacterial liquid and evenly spread it on the beef extract peptone solid medium, use a micro-sampler to take 5 μl of the melon seed gold fermentation preparation that has been filtered and sterilized by a 0.22 μm microporous membrane, and soak it in sterile water For sterilized filter paper with a diameter of 6mm, stick the drug-containing filter paper on the bacteria-coated medium, incubate at 37°C for 24 hou...

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Abstract

The invention relates to a polygala japonica fermenting oral liquid with anti-bacterial and anti-inflammatory activity, which is prepared by using polygala japonica, sticky rice and liqueur koji as raw materials and adopting the steps of removing protein and polysaccharose after solid fermentation, drying by distillation after extracting numeral butanol, dissolving extract with distilled water and adding a sweetener. In-vitro anti-bacterial experiments show that the polygala japonica fermenting oral liquid has a certain inhibition effect on staphylococcus aureus, colon bacillus, bacillus subtilis and pseudomonas, especially stronger inhibition effect on the staphylococcus aureus. Anti-inflammatory experiments show that the welling inhibition ratio for rats is 42.52 percent in experiments on rat's auricular swelling induced by dimethylbenzene. Pain-easing experiments show that the pain-easing inhibition ratio for the rats is 58.08 percent in rats twist pain-easing experiments, which shows that the polygala japonica fermenting oral liquid has stronger anti-bacterial and anti-inflammatory functions. In acute toxicity experiments, the maximum tolerated dose of the rats is 13.3g / kg, which shows that the polygala japonica fermenting oral liquid has no side and toxic effects on the rats.

Description

technical field [0001] The invention belongs to the field of antibacterial, anti-inflammatory and analgesic drugs, and relates to a preparation derived from the fermented product of melon seed gold. Background technique [0002] Guazijin is the whole herb of Polyagla japonica HOUTT., which is believed by traditional Chinese medicine to relieve phlegm and relieve cough, dissipate blood stasis and stop bleeding, calm the mind and calm the nerves, relieve heat and reduce swelling, etc. It is mainly used to treat cough, phlegm, bone Joint tuberculosis, multiple abscesses, acute tonsillitis, pharyngitis, palpitations, insomnia, urinary system stones, boils and tumors, etc. "Chinese Medicinal Plant Illustrated Book" believes that Melon Seed Gold: "Root: It is a sedative and expectorant agent, which can improve intelligence and calm the nerves, dissipate depression and reduce phlegm, and reduce carbuncle. Treat bronchitis, pneumonia, cough and phlegm, palpitations, forgetfulness, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/69A61P29/00A61P31/04C12G3/02
Inventor 刘明星朱婷童庆
Owner WUHAN MAIDESEN MEDICAL TECH
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