Dandeng Tongnao tablets and preparation process thereof

A technology of Dan Deng Tongnao and Salvia miltiorrhiza, applied in the directions of pill delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of sticky preparations, short use and storage time, caking and other problems, to achieve the effect of easy disintegration, dissolution and bioavailability not easily changed

Inactive Publication Date: 2010-09-15
九瑞健康股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The active ingredient of Dandeng Tongnao preparation is the water or alcohol extract of traditional Chinese medicine. These traditional Chinese medicine extracts take a large amount of extract and have strong hygroscopicity, that is, Chinese medicine extract is very easy to absorb moisture in the air during storage As a result, the granules will absorb moisture and become soft, and the preparation will become sticky, agglomerated and sticky. After a long time, the product quality will be seriously affected. The current validity period of capsules and soft capsules is set at one and a half years. If the intermediate links of production and distribution are added, the preparation The actual use and storage time of Dandeng Tongnao preparations are very short. The preparation of Dandeng Tongnao preparations into tablets and the coating protection treatment are helpful to overcome the above defects. The film coating will also gradually appear discoloration or cracks, so the current tablet still has room for improvement

Method used

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  • Dandeng Tongnao tablets and preparation process thereof
  • Dandeng Tongnao tablets and preparation process thereof
  • Dandeng Tongnao tablets and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Preparation of extract dry extract powder

[0038] Take 555g of Salvia miltiorrhiza, 555g of Erigeron breviscapine, 555g of Chuanxiong, and 835g of Pueraria lobata. Add water to decoct Chuanxiong and Pueraria lobata for three times, add 8 times the amount of water each time, for 1 hour for the first time, and 0.5 hours for the second and third times, filter. Combine the filtrates, concentrate the filtrates into a clear paste with a relative density of 1.08 to 1.14 (50°C to 60°C), add 2.8 times the amount of ethanol, stir well, heat to 60°C, let stand for 24 hours, filter, and recover the ethanol from the filtrate under reduced pressure , concentrated into a thick paste with a relative density of 1.25 to 1.30 (50°C to 60°C), and dried under vacuum below 85°C to form a dry paste; dandelion was impregnated with 85% ethanol three times, adding 6 times the amount of 85% ethanol each time, the first time Immerse for 48 hours, soak for 24 hours for the second and thi...

Embodiment 2

[0040]Take one tenth of the dry extract powder of the extract in Example 1, add 50g of starch and 70g of microcrystalline cellulose, mix well, granulate, add an appropriate amount of magnesium stearate, mix well, press into 100 tablets, and wrap film Clothes, get it.

Embodiment 3

[0042] Take one tenth of the dry extract powder of the extract in Example 1, add 40 g of starch and 80 g of microcrystalline cellulose, mix well, granulate, add an appropriate amount of magnesium stearate, mix well, press into 100 tablets, and wrap film Clothes, get it.

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Abstract

The invention discloses Dandeng Tongnao tablets and a preparation process thereof, relating to the field of traditional Chinese medicines, and characterized in that a specific auxiliary material combination is utilized to improve the moisture absorption capability of the tablets. The auxiliary material combination used in the invention is the combination of starch and microcrystalline cellulose. The dosages of the starch and the microcrystalline cellulose are respectively 40-60g and 60-80g in every 1000 Dandeng Tongnao tablets. The tablets prepared by the invention have better anti-moisture absorption ability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a Dandeng Tongnao tablet and a preparation process thereof. Background technique [0002] Dandeng Tongnao preparation is composed of four traditional Chinese medicines: Salvia miltiorrhiza, Erigeron breviscapus, Chuanxiong, and Pueraria lobata. Yi medicine believes that the efficacy of Dandeng Tongnao preparation is: woge nu wo leather clothes, Ximi and slaves. Traditional Chinese medicine believes that Dandeng Tongnao The preparation has the effects of promoting blood circulation and removing blood stasis, dispelling wind and dredging collaterals. It is clinically used for apoplexy caused by blood stasis blocking collaterals, syndrome of meridians. [0003] At present, the dosage forms of Dandeng Tongnao preparations for clinical application include capsules, soft capsules and tablets. The active ingredient of Dandeng Tongnao preparation is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61K47/38A61P9/10
Inventor 王保明
Owner 九瑞健康股份有限公司
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