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Method for detecting quality of bezoar snake bile bulbus fritilariae liquid

A quality detection method and technology of bezoar snake gallbladder, applied in the field of quality inspection of bezoar snake gallbladder and Chuanbei liquid, can solve the problems of no quantitative detection method, unable to reflect the quality of traditional Chinese medicine compound preparations, weak spots, etc.

Inactive Publication Date: 2010-09-15
江西南昌桑海制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are only two chemical identification reactions in the quality control method of the Bezoar Shedan Chuanbei liquid, which are the chemical identification of artificial bezoar and Fritillaria chinensis, and the thin-layer chromatography identification of artificial bezoar, and there is no quantitative detection method. Obviously, the above-mentioned quality detection method cannot reflect the quality of the Chinese medicine compound preparation
In addition, the thin-layer chromatography of existing artificial bezoar has weak spots for identifying the test product.

Method used

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  • Method for detecting quality of bezoar snake bile bulbus fritilariae liquid
  • Method for detecting quality of bezoar snake bile bulbus fritilariae liquid
  • Method for detecting quality of bezoar snake bile bulbus fritilariae liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Example 1 Bezoar Chuanbei snake bile fluid

[0099] Artificial bezoar 1.6g Chuan Fritillaria 48.4g Snake bile 8.1g Menthol 0.04g

[0100] Take artificial bezoar and grind it, soak it with 5 times the amount of ethanol for 24 hours, filter to make artificial bezoar extract; grind Fritillaria chinensis into coarse powder, use 70% ethanol as solvent for percolation, collect percolation liquid, Concentrate to a volume / weight ratio of 1:1 to obtain the extract of Fritillaria sichuanensis; take 180g of sucrose, 80g of honey and add water to make a syrup, mix with snake bile, extract of artificial bezoar, liquid extract of Fritillaria sichuanensis, and add 0.04g of menthol and ethylparaben 0.5g, add water to adjust the total amount to 1000ml, stir well, filter, potting, and sterilize to obtain.

[0101] Dosage: Take orally, 10ml each time, three times a day.

[0102] Every 1ml of said bezoar, Chuanbei snake bile fluid is converted into the amount of raw material medicine, wh...

Embodiment 2

[0103] Example 2 Bezoar Chuanbei Snake Gallbladder Syrup

[0104] Artificial bezoar 1.2g Chuan Fritillaria 50g Snake bile 7.8g Menthol 0.04g

[0105] According to the conventional process, add an appropriate amount of auxiliary materials to make 1000ml of syrup.

[0106] Dosage: Take orally, 10ml each time, three times a day.

[0107] Every 1ml of said bezoar, Chuanbei snake gall syrup is converted into the amount of raw material, which is equivalent to 0.059g.

Embodiment 3

[0108] Example 3 Niuhuang Chuanbei Shedan Soft Capsules

[0109] Artificial bezoar 2.0g Chuan Fritillaria 60g Snake bile 6g Menthol 0.04g

[0110] According to the conventional process, add appropriate amount of auxiliary materials to make soft capsules, each 0.45g.

[0111] How to take: 1 capsule each time, three times a day.

[0112] The content of every 1g of the Niuhuang Chuanbei Shedan soft capsule is converted into the amount of raw material, which is equivalent to 1.508g.

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Abstract

The invention discloses a method for detecting the quality of bezoar snake bile bulbus fritilariae liquid which consists of the following raw medicament components in part by weight: 1.0 to 2.0 parts of artificial bezoar, 40 to 60 parts of unibract fritillary bulb, 6.0 to 10 parts of snake bile and 0.03 to 0.05 part of menthol. The method comprises the following steps of chemical identification of the unibract fritillary bulb, thin layer chromatography identification of the artificial bezoar, thin layer chromatography identification of the snake bile, and efficient liquid-phase method content determination of bile acid. The invention also discloses a preparation process and preferential raw material components of the bezoar snake bile bulbus fritilariae liquid. The method for detecting the quality can reflect the preparation quality of the bezoar snake bile bulbus fritilariae liquid from a plurality of aspects so as to ensure the curative effect and the medication safety.

Description

technical field [0001] The invention relates to a quality detection method of a compound traditional Chinese medicine preparation, in particular to a quality detection method of Bezoar Shedan Chuanbei Liquid for treating hot phlegm, dry phlegm cough, cough, yellow phlegm or dry cough, and unpleasant phlegm. Background technique [0002] The Bezoar Shedan Chuanbei liquid made from artificial bezoar, Chuan Fritillaria and snake bile has the functions of clearing away heat, reducing phlegm and relieving cough. It is used for cough with hot phlegm and dry phlegm. accurate. In the prior art, there are only two chemical identification reactions in the quality control method of the Bezoar Shedan Chuanbei liquid, which are the chemical identification of artificial bezoar and Fritillaria chinensis, and the thin-layer chromatography identification of artificial bezoar, and there is no quantitative detection method. Obviously, the above-mentioned quality detection method cannot reflec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P11/14G01N31/02G01N30/90G01N30/36A61K35/413A61K35/58A61K35/583
Inventor 罗国仕邹俊武谢志勇张龙辉杨俊华虞井红李振华
Owner 江西南昌桑海制药有限责任公司
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