Thienopyridine derivatives, preparation method and application thereof

Abstract

The invention belongs to the technical field of drugs resisting platelet aggregation, in particular to thienopyridine derivatives with the structure of a formula I and salts thereof, wherein n is equal to 0 and 1; R1 is C1-C4 alkyl; R2 and R3 are simultaneously or respectively hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halogen and halogenated methyl; and R4 is C1-C4 alkyl. The invention also relates to a preparation method of the compounds, and discloses a drug composition with the compounds or salts thereof as active effective components, and application of the compounds in preparing the drugs for resisting the platelet aggregation.

Description

technical field The invention belongs to the technical field of medicine, more specifically, relates to a compound with anti-platelet aggregation effect and a preparation method thereof. Background technique Thrombosis can lead to acute myocardial infarction, stroke, pulmonary embolism and other diseases of the heart, brain, and pulmonary circulation, threatening human health and life, and is also a common complication in surgery and a factor of reocclusion after interventional angioplasty. Although thrombolytic therapy, interventional therapy and even surgical treatment carried out in recent years have made remarkable progress in the treatment of acute myocardial infarction and cerebral infarction, the success rate of patient rescue has been greatly improved, and the quality of life has also been significantly improved, but cardiovascular and cerebrovascular After all, the disability rate is as high as 30%. Therefore, the development of drugs for the prevention and treatme...

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The results of its clinical controlled trial with clopidogrel showed that prasugrel was more effective in reducing deaths from non-fatal heart disease and stroke, but caused patients to bleed more

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