Application of 5'-AMP for treating urarthritis

A gouty arthritis and usage technology, applied in the field of 5′-AMP for the treatment of gouty arthritis, can solve the problems of bone marrow suppression, large side effects, prone to gastrointestinal symptoms, etc., and reduce joint cavity swelling degree of effect

Inactive Publication Date: 2011-01-19
苗志敏 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 5'-AMP is the English alias of 5'-adenylic acid, and its Chinese aliases also include adenosine-5'-phosphate (+4°C), adenosine 5'-phosphate, 5'-phosphate adenosine, 5'- Adenosine-phosphate, etc., so far no report on the use of 5'-AMP for the treatment of gouty arthritis
At present, colchicine, a specific drug for the clinical treatment of acute gouty arthritis, has relatively large side effects, and is prone to adverse reactions such as gastrointestinal symptoms and bone marrow suppression. Therefore, it is urgent to develop a drug with specific effects and relatively small side effects

Method used

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  • Application of 5'-AMP for treating urarthritis
  • Application of 5'-AMP for treating urarthritis
  • Application of 5'-AMP for treating urarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention uses 5'-AMP to induce hypothermia to treat gouty arthritis, and observes the degree of swelling of the joint cavity and the infiltration of inflammatory cells, so as to provide possible theoretical guidance and basis for clinically developing new drugs for gouty arthritis.

[0019] Content and requirements:

[0020] Using the rat gouty arthritis animal model, H&E staining of pathological sections and other technical methods, low temperature was applied to the research of gouty arthritis for the first time, the swelling degree of the joint cavity was measured, and the connective tissue in the joint cavity was subjected to routine pathological analysis.

[0021] Technical indicators:

[0022] 1. Use uric acid and sodium hydroxide to prepare urate crystals, check with a polarized light microscope, and confirm that crystals are formed, see figure 1 and figure 2 .

[0023] 2. After intraperitoneal injection of 5'-AMP in rats, the body temperature of...

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Abstract

The invention discloses application of 5'-AMP in preparing a drug for treating urarthritis. Proved by relevant tests, on one hand, the 5'-AMP can obviously reduce the swelling degree of a urarthritis joint cavity; and on the other hand, the 5'-AMP can obviously reduce the infiltration of a connective tissue inflammatory cell in the urarthritis joint cavity when being used for treating the urarthritis. The 5'-AMP is used as an injection drug to treat the urarthritis and does not have obvious damage to animals, and the adverse side effect is not discovered. The 5'-AMP is a drug which is safe and reliable and can be used for treating the urarthritis.

Description

technical field [0001] The present invention relates to the new use of 5'-AMP for treating diseases, in particular to the use of 5'-AMP for treating gouty arthritis. Background technique [0002] Gout is a group of heterogeneous metabolic diseases caused by long-term purine metabolism disorder or decreased uric acid excretion. The clinical features of gout are hyperuricemia, recurrent acute arthritis, tophi deposition, tophi chronic arthritis and joint deformities, involving the kidneys to cause chronic interstitial nephritis and kidney stones, etc., often complicated by cardiovascular and cerebrovascular diseases And life-threatening, prone to men and menopausal women. Gout is divided into two types: primary (genetic, enzyme deficiency, etc.) and secondary (chronic hemolytic anemia, hyperparathyroidism, various kidney diseases, etc.), and the prerequisite for its pathogenesis is hyperuricemia, hyperuricemia Symptoms refer to the uric acid content in serum at 37°C exceedin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P19/02A61P19/06A61P19/04A61P29/00
Inventor 苗志敏李长贵王云龙
Owner 苗志敏
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