Composition for detecting rheumatoid arthritis immune antibody by colloidal gold lateral chromatography

A technology of lateral flow chromatography and immune antibody, which is applied in the direction of analytical materials, biological tests, measuring devices, etc., can solve the problem of waiting for further independent clinical research, long time for detection, no data to support BiP rheumatoid arthritis, etc. question
CN102023219AActive Publication Date: 2011-04-20SHANGHAI RONGSHENG BIOLOGICAL PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI RONGSHENG BIOLOGICAL PHARM CO LTD
Publication Date
2011-04-20

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Abstract

The invention discloses a composition for detecting a rheumatoid arthritis immune antibody by colloidal gold lateral chromatography. The composition comprises a cyclic citrullinated peptide (CCP) peptide composition, a macromoleclar polymer and a lateral chromatography detection medium, wherein the macromoleclar polymer is combined with the lateral chromatography detection medium in a covalent ornon-covalent form; the CCP peptide composition comprises CCP peptide I and CCP peptide II and is covalently or non-covalently combined with the macromoleclar polymer; and the molar ratio of the CCP peptide I to the CCP peptide composition is 0 to 1. The composition can realize rapid in-vitro detection of the rheumatoid arthritis immune antibody in 15 minutes, bring convenience to self-diagnosis of a patient and provide reference for immediately learning disease progression.
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Description

technical field

[0001] The invention relates to a composition for detecting rheumatoid arthritis antibodies, in particular to a composition for detecting rheumatoid arthritis immune antibodies by colloidal gold lateral flow chromatography, so as to realize rapid and accurate detection of rheumatoid arthritis immune antibodies. Background technique

[0002] Clinically, autoimmune diseases mainly include systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, dermatomyositis, polymyositis, systemic (multiple) sclerosis, scleroderma, etc. These diseases were once named " Connective tissue disease", later both abroad and domestically classified them as rheumatic diseases.

[0003] Rheumatoid arthritis (RA) is a relatively common systemic autoimmune disease mainly manifested by chronic polyarticular inflammation. Very painful. The incidence of the disease is 0.5-1% worldwide, and the incidence in China is about 0.36%. The age of onset of patients is mostly betw...

Claims

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