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Method for preparing special component of traditional Chinese medicine Indian trumpetflower seed, namely Oroxin B

A technology of cypressoside and cypressoside, applied in the field of separating and purifying the preparation of exclusive component cymoxidin B, can solve the problems of environmental and human health effects, toxic and side effects, etc.

Inactive Publication Date: 2011-04-27
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Application Information

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Problems solved by technology

These two methods have all used organic solvents (chloroform and benzene) that have toxic and side effects on the human body, and a large amount of use will have a certain impact on the environment and people's health.

Method used

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  • Method for preparing special component of traditional Chinese medicine Indian trumpetflower seed, namely Oroxin B
  • Method for preparing special component of traditional Chinese medicine Indian trumpetflower seed, namely Oroxin B
  • Method for preparing special component of traditional Chinese medicine Indian trumpetflower seed, namely Oroxin B

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Embodiment Construction

[0006] Cut the medicinal material of Oryza sativa into pieces, add 8 times the amount of 70% ethanol to heat and reflux for 3 times, filter, concentrate the filtrate and extract with water-saturated n-butanol, combine the n-butanol liquid, and recover the n-butanol to obtain the extract. Then extract the n-butanol to obtain the extract, separated by a polyamide column, first eluted with distilled water until the eluent is colorless, discarded the water, and then eluted with 10%-40% methanol to colorless, collect the eluent It is recovered to a small volume and purified by dextran gel, the main color band is collected, the solvent is recovered, and the precipitate is precipitated and recrystallized to obtain oriloside B with a purity of more than 98%.

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Abstract

Indian trumpetflower seed is a common traditional Chinese medicine and contains main chemical components of flavonoid compounds, such as baicalein, chrysin, Oroxin A, Oroxin B, baicalin and the like, wherein the Oroxin B is a special component of the Indian trumpetflower seed and can serve as an important index for quality control of the Indian trumpetflower seed medicinal material. An identification method and a contrast for the special component have not been present under the item of Indian trumpetflower seed in the first part of 2005 version Chinese Pharmacopoeia. The Oroxin B prepared by separation serving as a contrast in a thin-layer identification method for the specificity of the traditional Chinese medicine Indian trumpetflower seed, has been written under the item of the traditional Chinese medicine Indian trumpetflower seed in the first part of 2010 version Chinese Pharmacopoeia, and is about to serve as the content of Chinese Pharmacopoeia to be published and implemented. A method for preparing the special component of traditional Chinese medicine Indian trumpetflower seed, namely Oroxin B is invented by scientific research personnel of Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences through years of experiments. The Oroxin B is prepared by ethanol extraction, polyamide separation, and glucan gel purification.

Description

1. Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a method for separating and purifying the specific component oroxylin B from the traditional Chinese medicine Oroxylin. 2. Background technology [0002] Flavonoids are compounds with the core structure of 2-phenylchromonone, which are widely distributed in plants and possess various biological activities. Oroxylina is a kind of more commonly used traditional Chinese medicine, and its chemical components are mainly flavonoids, including baicalein (Scutellarein), chrysin (Chrysin), Hispidulin (Hispidulin), oroxylin A (Oroxin A). Oroxin B, Oroxindin, Tetuin, Baicalin, etc. Among them, Oroxin B is the exclusive ingredient of Oroxin B and can be used as a An important indicator for the quality control of butterfly medicinal materials. At present, the first specific component of the Pharmacopoeia of the People's Republic of China has not been included ...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08
Inventor 李曼玲康琛张强仝会娟
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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