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Use of IL-4 in preparing medicine for curing serious hepatitis

A severe hepatitis and drug technology, applied in the field of medicine, can solve the problem of severe hepatitis without IL-4

Active Publication Date: 2011-05-11
WEST VAC BIOPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report that IL-4 can effectively treat severe hepatitis

Method used

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  • Use of IL-4 in preparing medicine for curing serious hepatitis
  • Use of IL-4 in preparing medicine for curing serious hepatitis
  • Use of IL-4 in preparing medicine for curing serious hepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment one treats severe hepatitis with IL-4

[0023] (1) Materials

[0024] 1. Experimental animals

[0025] BALB / c mice (7-8 weeks, female) were purchased from the Animal Research Center of Sichuan University, weighing 18-22g;

[0026] 2. Main reagents, materials and kits

[0027] 1) IL-4 (purchased from PROSPEC, Israel, Cat. No. CYT-282)

[0028] 2) D-GalN, LPS: purchased from Sigma.

[0029] 3) IL-1β, TNF-α, IL-6, IL-10, IFN ELISA kits: purchased from Xinbosheng Company.

[0030] 4) TUNEL detection kit (DeadEnd Fluorometric TUNEL System): purchased from Promega Company.

[0031] 5) ERK1, ERK2, P-ERK, iNOS antibodies: purchased from Zhongshan Jinqiao Company.

[0032] 6) Horseradish peroxidase (HRP)-labeled rabbit anti-mouse IgG (H+L): purchased from Beijing Zhongshan Biological Company.

[0033] 7) DAB Chromogenic Kit: purchased from Beijing Zhongshan Jinqiao Biotechnology Co., Ltd.

[0034] 8) Western blotting chemiluminescence detection kit: purchased ...

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Abstract

The invention belongs to the field of biological medicine and aims to solve the technical problem of providing a new use of IL-4 (interleukin-4). Particularly, the invention provides a use of IL-4 in preparing medical composition for serious hepatitis. When the dose of IL-4 is within the range of 0.1 mu.g / kg / d to 5 mu.g / kg / d, good effect can be achieved in curing serious hepatitis. The invention provides a new choice for the treatment of serious hepatitis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of interleukin-4 (IL-4) in the preparation of medicines for treating severe hepatitis. Background technique [0002] Severe hepatitis B develops rapidly and has a poor prognosis. It is a disease that seriously endangers human health. Its pathogenesis is complex and has not been fully elucidated so far, but most scholars agree with the second-hit theory, believing that the first hit causes liver damage and liver barrier dysfunction, and the subsequent intestinal-derived endotoxemia activates monocytes. The phagocyte system releases a large number of cytokines and inflammatory mediators, forming a second blow, further damaging the liver, aggravating liver cell necrosis, and leading to liver failure. Therefore, lipopolysaccharide (LPS), the main toxic component of endotoxin, is the core molecule of the important pathogenic mechanism of liver failure. [0003] Mice sensi...

Claims

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Application Information

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IPC IPC(8): A61K38/20A61P1/16
Inventor 李炯魏于全
Owner WEST VAC BIOPHARMA CO LTD
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