Application of Hedraaponin C in preparation of medicine for treating and preventing acute kidney injury

A technology for acute kidney injury, which is applied in the field of medicine, can solve the problem of high mortality in AKI patients, and achieve the effect of reducing the degree of pathological damage

Pending Publication Date: 2022-03-01
GUANGXI XINHAI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite clinical use of renal replacement therapy, etc., the mortality rate of AKI patients infected with sepsis is as high as 70%.

Method used

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  • Application of Hedraaponin C in preparation of medicine for treating and preventing acute kidney injury
  • Application of Hedraaponin C in preparation of medicine for treating and preventing acute kidney injury
  • Application of Hedraaponin C in preparation of medicine for treating and preventing acute kidney injury

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Embodiment Construction

[0022] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0023] It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0024] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0025] The compound of formula I can be administered alone as a medicament or in the form of a pharmaceutical composition comprising the compound of formula I or a pharmaceutically acceptable salt, solvate, prodrug or derivative thereof. Medicines or pharmaceutical compositions include main ingredients and auxiliary materials, such a...

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Abstract

The invention discloses an application of Hedraaponin C in preparation of a medicine for treating and preventing acute kidney injury. The structural formula of the Hedraaponin C is as shown in formula (I). The Hedraaponin C has a protective effect on kidney tissues of an endotoxemia mouse AKI model.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to the use of Hederasaponin C in the preparation of medicines for the treatment and prevention of acute kidney injury. Background technique [0002] Acute kidney injury (AKI) is the sudden loss of kidney function, involving various etiologies and pathophysiological processes, with high morbidity and mortality. Sepsis can cause multiple organ dysfunction in the body, and is a systemic inflammatory response syndrome. main reason. Despite clinical use of renal replacement therapy, the mortality rate of AKI patients infected with sepsis is as high as 70%. Therefore, there is an urgent need to develop a drug for the treatment of renal injury in order to improve and prevent the mortality of renal injury. [0003] Hederasaponin C is one of the main active ingredients in Pulsatillae. Pulsatilla has the functions of clearing away heat and detoxifying, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P13/12A61P29/00A61P31/04
CPCA61K31/704A61P13/12A61P29/00A61P31/04
Inventor 高红伟杨世林
Owner GUANGXI XINHAI PHARM TECH CO LTD
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