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Preparation technology and production method of new integrative formulation of true warrior decoction

An integrated and production method technology of Zhenwu Decoction, which is applied in pill delivery, pharmaceutical formula, suppository delivery, etc., to achieve the effect of wide target distribution

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no identical or similar literature reports at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Prepare the following raw materials by the aforementioned method:

[0042] Extracts, nanoparticles, microcapsules, nanoparticles.

[0043] The composition of the raw materials used to make the active ingredients is——

[0044] 9 parts of Poria cocos, 9 parts of Zhifuzi, 6 parts of Atractylodes macrocephala, 9 parts of white peony, and 9 parts of ginger.

[0045] Its manufacturing process is as follows:

[0046] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform ...

Embodiment 2

[0048] Prepare the following raw materials by the aforementioned method:

[0049] Water decoction concentrate, nanoliposome, nanoemulsion, microemulsion, nanosuspension.

[0050] The composition of the raw materials used to make the active ingredients is——

[0051] 9 parts of Poria cocos, 9 parts of Zhifuzi, 6 parts of Atractylodes macrocephala, 9 parts of white peony, and 9 parts of ginger.

[0052] Its manufacturing process is as follows:

[0053] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing...

Embodiment 3

[0055] Prepare the following raw materials by the aforementioned method:

[0056] Extract, solid lipid nanoparticles, nanoemulsion.

[0057] The composition of the raw materials used to make the active ingredients is——

[0058] 9 parts of Poria cocos, 9 parts of Zhifuzi, 6 parts of Atractylodes macrocephala, 9 parts of white peony, and 9 parts of ginger.

[0059] Its manufacturing process is as follows:

[0060] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, the drug conten...

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Abstract

The invention relates to a preparation technology and a production method of a new integrative formulation of true warrior decoction. The true warrior decoction comprises the following raw materials in part by weight: 9 parts of Indian buead, 9 parts of prepared common monkshood daughter root, 6 parts of largehead atractylodes rhizome, 9 parts of white paeony root and 9 parts of dried ginger. The production process comprises the following steps of: alcohol / water extracting, ultrasonic crushing extracting, microwave extracting, decocting and concentrating, spray drying, high-pressure homogenizing, nanometer grinding, nanometer particle preparation and the like. The preparation technology and the production method have the advantages of multi-synergetic effect, multi-targeting effect and the like of nanometer traditional Chinese medicines. By large-scale industrial production, the production cost can be reduced substantially, the quality of products can be improved, and the targeting and slow controlled release properties of medicaments are higher; and a prepared membrane agent also can be applied to the skin of human bodies for treatment by transdermal absorption.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Zhenwu Decoction, and also relates to a preparation technology of a new integrated dosage form of Zhenwu Decoction and a production method thereof. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. [0003] Traditional Chinese medicine compound prescription embodies the holistic view, system theory, and syndrome differentiation and treatment principles of traditional Chinese medicine treatment, which emphasizes strengthening the body and eliminating pathogenic factors, and treating both symptoms and root causes. What a single ingredient can sum up. The efficacy of the compound medicine is not only related to the active substances or groups of effective substances, but also related to the auxiliary components. When the traditional Chinese medicine pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/02A61K9/08A61K9/10A61K9/12A61K9/14A61K9/16A61K9/20A61K9/22A61K9/48A61K9/70A61K9/00A61P13/12A61P7/10A61P5/14A61P1/00A61P27/16A61P11/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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