Preparation technology and production method for integrated new formulation of licorice and monkshood decoction

A production method and new dosage form technology, which is applied in the field of preparation of integrated new dosage forms of Gancao Fuzi Decoction, to achieve the effect of wide target distribution and strong slow and controlled release performance

Inactive Publication Date: 2013-01-30
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic and foreign databases were used to search for novelties, and the following conclusions were drawn based on the reading, analysis and comparison of domestic and foreign literature: the innovation of the project of "developing new integrated dosage forms of nano-drugs with combined technology": 1) the use of nano-scale traditional Chinese medicine rich in trace elements Nanospheres, nanocapsules, polymer micelles, and solid ester nanoparticles of different particle sizes are prepared with different drug carriers such as powder, drug monomer, effective part, effective part group, traditional Chinese medicine extract, decoction concentrate, etc. , magnetic nanoparticles, immune nanoparticles, nanoemulsions, suspensions, vesicles, dru

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0043] [Example 1]

[0044] The following raw materials were prepared according to the aforementioned method: extract, nanoparticles, microcapsules, and nanoparticles.

[0045] The composition of the raw materials made into the active ingredients according to the weight ratio is ——

[0046] 6 parts of roasted licorice, 12 parts of aconite, 6 parts of Baizhu, 12 parts of Guizhi.

[0047] The manufacturing process is as follows: After mixing the extract, nanoparticles, microcapsules, and nanoparticles in a 4:2:2:2 ratio in a GMP10000 clean room, use the 2010 edition of the "Chinese Pharmacopoeia" Part I preparations and hard capsules Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with an automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, sticking labels, coding, and packing. Finally, uniform instant sterilization according to the production batch, and i...

Example Embodiment

[0048] [Example 2]

[0049] The following raw materials were prepared according to the aforementioned method: decoction concentrate, nano liposomes, nano emulsions, and micro emulsions.

[0050] The composition of the raw materials made into the active ingredients according to the weight ratio is ——

[0051] 6 parts of roasted licorice, 12 parts of aconite, 6 parts of Baizhu, 12 parts of Guizhi.

[0052] The manufacturing process is as follows: After mixing the decoction concentrate, nanoliposomes, nanoemulsions, and microemulsions at a ratio of 4:2:2:2 in a GMP10000 clean room, use the first preparation of the 2010 Chinese Pharmacopoeia Some soft capsules are standard, no auxiliary materials and preservatives are added, and the soft capsules are divided into soft capsules by the automatic soft capsule filling machine. Then carry out internal and external packaging such as counting, bottling, sealing, sticking labels, coding, and packing. Finally, uniform instant sterilization accor...

Example Embodiment

[0053] 〖Example three〗

[0054] The following raw materials were prepared according to the aforementioned method: extract, nano-particles, and nano-emulsion.

[0055] The composition of the raw materials made into the active ingredients according to the weight ratio is ——

[0056] 6 parts of roasted licorice, 12 parts of aconite, 6 parts of Baizhu, 12 parts of Guizhi.

[0057] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, adopt the 2010 edition of the "Chinese Pharmacopoeia" Part I of the preparation and partial film standards, and the film forming materials are used Polyvinyl alcohol, made into film. Then carry out inner and outer packaging such as boxing, sealing, sticking labels, coding, and boxing. Finally, uniform instant sterilization according to the production batch, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, and each film is applied fo...

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Abstract

The present invention relates to a preparation technology and a production method for an integrated new formulation of a licorice and monkshood decoction, wherein the raw materials of active ingredients comprise: 6 parts by weight of honey-fried licorice, 12 parts by weight of monkshood, 6 parts by weight of bighead atractylodes rhizome, and 12 parts by weight of cinnamon twig. The production process of the integrated new formulation of licorice and monkshood decoction comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages, such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of licorice and monkshood decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of licorice and monkshood decoction can be realized simultaneously, and can be respectively taken in four time slices according to midnight-noon ebb-flow and qi and blood flowing rule of a human body. The integrated new formulation of licorice and monkshood decoction can be further prepared into films and transdermal agents which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body and can be directly absorbed through skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Gancao Fuzi Decoction, and also relates to a preparation technology of a new integrated dosage form of Gancao Fuzi Decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxi...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61P9/10A61P29/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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