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Preparation technology and preparation method of novel integrative Erchen decoction dosage form

A production method and integrated technology, applied in the directions of pill delivery, pharmaceutical formulation, suppository delivery, etc., can solve problems such as irritation, and achieve the effect of strong sustained and controlled release performance and wide targeted distribution.

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Modern pharmacological studies have proved that pinellia has antitussive and antiemetic effects; tangerine peel has a passive phlegm effect, has a mild stimulating effect on the stomach, can promote the secretion of digestive juices and eliminate intestinal gas; Function; licorice has the effect of antitussive and expectorant, preventing the occurrence of ulcer disease, in addition, it also has the effect of relieving intestinal spasm

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0041] The composition of the raw materials used to make the active ingredients is——

[0042] 15 parts of pinellia, 15 parts of tangerine peel, 12 parts of poria cocos, 6 parts of licorice, 5 parts of ginger, and 1 part of dark plum.

[0043] Its manufacturing process is as follows:

[0044] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the pro...

Embodiment 2

[0046] Prepare the following raw materials according to the aforementioned method: water decoction concentrate, nano liposome, nanoemulsion, microemulsion, nano suspension.

[0047] The composition of the raw materials used to make the active ingredients is——

[0048] 15 parts of pinellia, 15 parts of tangerine peel, 12 parts of poria cocos, 6 parts of licorice, 5 parts of ginger, and 1 part of dark plum.

[0049] Its manufacturing process is as follows:

[0050] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding...

Embodiment 3

[0052] Prepare the following raw materials according to the aforementioned method: extract, solid lipid nanoparticles, and nanoemulsion.

[0053] The composition of the raw materials used to make the active ingredients is——

[0054] 15 parts of pinellia, 15 parts of tangerine peel, 12 parts of poria cocos, 6 parts of licorice, 5 parts of ginger, and 1 part of dark plum.

[0055] Its manufacturing process is as follows:

[0056] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, th...

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Abstract

The invention relates to a preparation technology and preparation method of a novel integrative Erchen decoction dosage form. The composition for effective components comprises the raw materials in proportion by weight: 15 parts of pinellia ternate, 15 parts of dried tangerine peel, 12 parts of poria cocos, 6 parts of licorice root, 5 parts of ginger and 1 part of dark plum. The production process comprises the steps of: alcohol water extraction, ultrasonic grinding and extraction, microwave extraction, decocting and condensation, supersonic spraying and drying, high-pressure emulsion homogenization, nano grinding, nano particle preparation and the like. The preparation technology and the preparation method stress on the advantages of the multi-coordinate and multi-target effect in nano traditional Chinese medicines, and the like. After the industrialized production is realized, the production cost can be reduced to a larger extent, the product quality is improved, and the target and the slow controlled release of medicines are further enhanced. After being produced into a film agent, the integrative Erchen decoction agent can be applied to skins of a human body to realize the treatment through percutaneous absorption.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Erchen Decoction, and also relates to a preparation technology of a new integrated dosage form of Erchen Tang and a production method thereof. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. [0003] The main form of TCM clinical medication is the compound prescription of traditional Chinese medicine, which is the specific application of TCM prescriptions and prescriptions. It embodies the holistic view, system theory, and syndrome differentiation and treatment principles of TCM treatment, which emphasizes strengthening the body and eliminating pathogenic factors, and treating both symptoms and root causes. It is a multi-system, multi-target And multi-level treatment methods that play a full range of medicinal effects, all of which cannot be achieved...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/02A61K9/08A61K9/10A61K9/12A61K9/14A61K9/16A61K9/20A61K9/22A61K9/48A61K9/70A61K9/00A61P1/04A61P1/08A61P1/02A61P11/00A61P25/20A61P25/08A61P19/00A61P35/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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