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Scindapsus aureus extract for treating diabetic nephropathy and preparation method and application thereof

A technology of diabetic nephropathy and pothos, applied in the field of pothos extract, preparation and application for treating diabetic nephropathy

Inactive Publication Date: 2011-10-05
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the pharmacology of the extract of the pothos, especially in the treatment of diabetic nephropathy.

Method used

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  • Scindapsus aureus extract for treating diabetic nephropathy and preparation method and application thereof
  • Scindapsus aureus extract for treating diabetic nephropathy and preparation method and application thereof
  • Scindapsus aureus extract for treating diabetic nephropathy and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh and extract 1.1 kg of pothos flower medicinal material with 3 petroleum ether reflux for 3 times to obtain the reflux liquid and residue I of the small polar solvent;

[0027] TLC analysis of the reflux liquid of the small polar solvent showed no particularly obvious spots at 254nm and 365nm, and the concentrated sulfuric acid-vanillin color reagent was sprayed to show yellow (strip tailing), judging that this part mainly contains fatty acids and their esters class of compounds.

[0028] Residue I was extracted three times with 70% ethanol or methanol under reflux to obtain alcohol solvent reflux and residue II;

[0029] The alcohol solvent reflux liquid was detected by hydrochloric acid-magnesium powder color reaction, and at the same time, the absorbance was measured by spectrophotometry, and rutin was used as a control, and the extract was analyzed. The results determined that the component contained flavonoids.

[0030] The residue II was refluxed and extract...

Embodiment 2

[0037] The PE, EA, NB and RA prepared in Example 1 were evaluated for the activation effect of PPARβ and PPARγ. For specific conclusions, see Figure 1-8 ; The results showed that PE, EA, NB and RA all had the effect of activating PPARβ and PPARγ, among which the effects of PE and EA were obvious.

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Abstract

The invention discloses a scindapsus aureus extract for treating diabetic nephropathy and a preparation method and application thereof. Scindapsus aureus is provided to treat active positions of diabetic nephropathy. By adopting the invention, conditions are created for the improvement on developing new formulations or the change of an administration way.

Description

technical background [0001] Diabetic nephropathy is a common complication of diabetes. It is one of the manifestations of systemic microvascular disease in diabetes. The clinical features are proteinuria, progressive renal damage, hypertension, edema, and severe renal failure in the late stage. It is the main cause of death in diabetic patients. one. In recent years, with the prolongation of the average life expectancy of the Chinese population, changes in living and eating habits, and structural changes, the prevalence of diabetes has shown a linear upward trend, and due to the improvement of treatment methods, the survival time has increased, and kidney and other complications have also increased. According to the latest statistics, about 50 million people in my country are currently facing the threat of diabetes. In the United States, diabetic nephropathy accounts for the first place in end-stage renal failure, about 35% to 38%. The incidence of diabetic nephropathy in ty...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61P3/10A61P13/12A61K133/00
Inventor 钟国跃徐盼梁旭明林叶新杨丰庆
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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