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Hollyhock extract, preparation method and use for treating diabetes and its complications

A technology of hollyhocks and extracts, which can be applied in the directions of urinary system diseases, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of less hollyhock extracts, etc.

Active Publication Date: 2015-08-12
CHONGQING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the pharmacology of hollyhock extract

Method used

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  • Hollyhock extract, preparation method and use for treating diabetes and its complications
  • Hollyhock extract, preparation method and use for treating diabetes and its complications
  • Hollyhock extract, preparation method and use for treating diabetes and its complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh the hollyhock herb group, each 1.0kg, take one group and use 3L (60-90°C) petroleum ether (gasoline can also be used instead of petroleum ether in industrial production) to reflux and extract for 3 times to obtain a small polar solvent reflux liquid and residue I;

[0023] TLC analysis of the reflux liquid of the small polar solvent showed no particularly obvious spots at 254nm and 365nm, and the concentrated sulfuric acid-vanillin color reagent was sprayed to show yellow (strip tailing), judging that this part mainly contains fatty acids and their esters class of compounds.

[0024] Residue Ⅰ was reflux extracted with 80% ethanol or methanol for 3 times, and the amount of solvent was 5 times of the weight of the medicinal material to obtain alcohol solvent reflux liquid A and residue Ⅱ. Reserve sample alcohol solvent reflux liquid A; - The color reaction of magnesium powder was detected and identified. At the same time, spectrophotometry was used to measure the ...

Embodiment 2

[0032] Diabetic nephropathy (DN) is one of the microvascular complications of diabetes. With the rising incidence of diabetes, DN has become the main cause of end-stage renal disease. It has important clinical and social significance to explore its pathogenesis and prevention methods. Peroxisome proliferator-activated receptor (VEroxi-some proliferator-activated receptor, PPAR) is one of the ligand-activated transcription factors in the nuclear receptor superfamily, with three subtypes: PPARα, PPARβ (PPARβ / δ ), PPARγ.

[0033] Studies have found that PPARβ is widely distributed and is highly expressed in islets, cardiac muscle, skeletal muscle, adipose tissue, skin, and brain tissue. Studies have also found that in skeletal muscle, cardiac muscle, and adipose tissue, PPARβ can enhance the oxidation and utilization of fatty acids, and is an upstream regulator of fatty acid oxidase. PPARβ is therefore regarded as a new and powerful therapeutic target for metabolic syndrome. Ho...

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Abstract

The invention provides an abelmoschus manihot extract for treating diabetes mellitus and complications of diabetes mellitus, a preparation method and use of the extract. The application of the invention provides an active part of abelmoschus manihot for treating II-type diabetes mellitus and diabetic nephropathy; and a condition is created for development of a novel dosage form to improve or change the drug delivery route.

Description

technical field technical background [0001] Diabetic nephropathy is a common complication of diabetes. It is one of the manifestations of systemic microvascular disease in diabetes. The clinical features are proteinuria, progressive renal damage, hypertension, edema, and severe renal failure in the late stage. It is the main cause of death in diabetic patients. one. In recent years, with the prolongation of the average life expectancy of the Chinese population, changes in living and eating habits, and structural changes, the prevalence of diabetes has shown a linear upward trend, and due to the improvement of treatment methods, the survival time has increased, and kidney and other complications have also increased. According to the latest statistics, about 50 million people in my country are currently facing the threat of diabetes. In the United States, diabetic nephropathy accounts for the first place in end-stage renal failure, about 35% to 38%. The incidence of diabetic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P3/10A61P13/12
Inventor 杨宪杨水平张雪余晓东郭霞和七一兰作平况刚
Owner CHONGQING NORMAL UNIVERSITY
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