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Preparation technology of a new integrated dosage form of Simiao Yong'an Decoction

A new dosage form and integrated technology, applied in the field of preparation of a new integrated dosage form of Simiao Yong'an Decoction, can solve the problems of reducing hemolytic activity, unable to antagonize the inflammatory effect of group limbs, and reducing the release of PGE2 in inflammatory tissues of rats, etc. Strong sustained and controlled release performance and wide targeted distribution

Inactive Publication Date: 2011-12-21
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Angelica water decoction has significant inhibitory effect on acute and chronic inflammation caused by various inflammatory agents, and its anti-inflammatory effect still exists after removing bilateral adrenal glands; it can also reduce the release of PGE 2 in inflammatory tissues of rats, and reduce the Complement alternative hemolytic activity, but not antagonism of inflammatory effects of group limbs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0047] The composition of the raw materials used to make the active ingredients is——

[0048] 90 parts of honeysuckle, 90 parts of Scrophulariaceae, 60 parts of angelica, 30 parts of licorice.

[0049] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a s...

Embodiment 2

[0051] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0052] The composition of the raw materials used to make the active ingredients is——

[0053] 90 parts of honeysuckle, 90 parts of Scrophulariaceae, 60 parts of angelica, 30 parts of licorice.

[0054] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch ...

Embodiment 3

[0056] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0057] The composition of the raw materials used to make the active ingredients is——

[0058] 90 parts of honeysuckle, 90 parts of Scrophulariaceae, 60 parts of angelica, 30 parts of licorice.

[0059] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 12-72 hours. The application site: neck, chest, ...

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Abstract

The invention relates to a preparation technology of a new integrated dosage form of Simiao Yong'an Decoction. The raw material composition of the active ingredients is as follows: 90 parts of honeysuckle, 90 parts of scrophulariaceae, 60 parts of angelica and 30 parts of licorice. The preparation process includes: supersonic airflow pulverization, alcohol water extraction, ultrasonic pulverization extraction, water decoction and concentration, nanometer grinding, high-pressure milk homogenization, nanoparticle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a new integrated dosage form of Simiao Yong'an Decoction, and also relates to a preparation technology for a new integrated dosage form of Simiao Yong'an Decoction. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reduction and other reactions between inheren...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61P9/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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