Dentoidin sponginum and preparation method thereof

Abstract

The invention belongs to the field of pharmacy and medical technology and relates to a dentoidin sponginum and a preparation method thereof. The sponginum provided by the invention comprises 80-99wt% of dentoidin and 1-20wt% of collage sponge matrix, wherein the dentoidin is fixed on the collagen sponge through crosslinking in different weight ratios. The sponginum provided by the invention ensures that the dentoidin is filled into ill parts with bone defects, nonunion of bone, bone tissue atrophy, bone fracture, poor bone healing and the like, so that the dentoidin plays roles in inducing bone formation, promoting bone repair and promoting wound convergence.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a dental matrix sponge and a preparation method. The sponge can shape the tooth matrix very well, so that the tooth matrix can be better filled in bone defect, nonunion, bone tissue atrophy, fracture, poor bone union and other diseased parts, and it can be used continuously for a long time with an effective dose. It induces osteogenesis, promotes bone repair, and promotes wound convergence. Background technique

[0002] Dr. Urist from the United States discovered that decalcified bone matrix can induce the formation of bone and cartilage, and in 1965 he established the theory of osteoinductive repair centered on the induction of bone tissue formation by BMP in bone. Since then, scholars at home and abroad have conducted a lot of research on the theory of bone repair, and developed a series of osteogenic materials derived from organisms, mainly autologous bone materials and frozen...