Blood separation gel used for blood collection vessel and preparation method thereof

A blood separation and blood collection technology, applied in the direction of immiscible liquid separation, instruments, analysis materials, etc., can solve the problems of compatibility difference, loss of separation and barrier effect, and influence of test results, etc., to achieve good compatibility, Effects of improving physical characteristics and reducing detection errors and difficulties

Inactive Publication Date: 2012-01-11
SHANGHAI KEHUADIAGNOSITIC MEDICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method for sterilizing blood collection tubes is to complete the sterilization process by gamma rays or similar rays, and electron beam irradiation. Similar to radiation and electron beams, curing reactions will occur when sterilizing, thus losing the proper separation and barrier effect
In addition, there are also differences in the compatibility of the above-mentioned materials. Small molecules may be precipitated after blood centrifugation. In rare cases, oily floating substances may be produced on the upper layer of serum or plasma after centrifugation. These factors will affect the test results.

Method used

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  • Blood separation gel used for blood collection vessel and preparation method thereof
  • Blood separation gel used for blood collection vessel and preparation method thereof
  • Blood separation gel used for blood collection vessel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 26 parts by weight of chlorinated paraffin (52% degree of chlorination, specific gravity at 25°C is 1.255), 1 part by weight of dibenzylidene sorbitol, 65 parts by weight of polyisobutene (molecular weight 40000, specific gravity at 25°C is 0.92, Viscosity at 100°C is 30000mPa·s), put it into the planetary mixer, close the cover, stir while heating up, when the temperature rises to 120°C, keep constant temperature, continue stirring for 1 hour, so that all components are fully dissolved and mixed; cool to Below 60°C, add 8 parts by weight of nano-silica (hydrophobic fumed silica after dimethylpolysiloxane post-treatment, particle size 12nm, specific surface area 110m2 / g, compacted density about 50g / l ), close the lid, decompress and evacuate, and control the negative pressure at -0.09Mpa to continue stirring for 1 hour. After cooling to room temperature, take out the prepared blood separation gel.

Embodiment 2

[0024] Take by weighing 29 parts by weight of chlorinated paraffin (chlorination degree is 70%, specific gravity is 1.255 at 25 DEG C), 0.81 parts by weight of dibenzylidene sorbitol, 60 parts by weight of polyisobutylene (molecular weight 950, specific gravity at 25 DEG C is 0.89, Viscosity at 40°C is 1.6Pa·s) into the planetary mixer, close the lid, and stir while heating up. When the temperature rises to 120°C, keep constant temperature and continue stirring for 1 hour to fully dissolve and mix the components; cool to 60°C Below ℃, add 10.19 parts by weight of nano-silica (hydrophobic fumed silica after dimethyl polysiloxane treatment, particle size 12nm, specific surface area 110m2 / g, compacted density about 50g / l) Close the lid, depressurize and evacuate, control the negative pressure at -0.09Mpa and continue stirring for 1 hour. After cooling to room temperature, take out the prepared blood separation gel.

Embodiment 3

[0026] Take by weighing 20 parts by weight of chlorinated paraffin (52% in degree of chlorination, specific gravity at 25°C is 1.255, viscosity 1.6Pa·s), 0.8 parts by weight of dibenzylidene sorbitol, 65 parts by weight of polyisobutene (molecular weight 850, The specific gravity is 0.88 at 25°C, the viscosity is 1.4Pa s) into the planetary mixer, close the lid, and stir while heating up. When the temperature rises to 120°C, keep constant temperature and continue stirring for 1 hour to fully dissolve and mix the components. be cooled to below 60°C, add 14.2 parts of nano-silica (hydrophobic fumed silica after dimethylpolysiloxane post-treatment, particle diameter 12nm, specific surface area 110m2 / g, compacted density approx. 50g / l) and close the lid, decompress and vacuumize, keep the negative pressure at -0.09Mpa and continue to stir for 1 hour. After cooling to room temperature, take out the prepared blood separation gel.

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Abstract

The invention relates to the technical field of blood collection equipment separation gel manufacture, and in particular relates to a blood separation gel used for a blood collection vessel and a preparation method thereof. After the blood separation gel is mixed with blood, thixotropy is caused by shearing force to divide the blood into three layers namely hemocyte visible components/ separation gel/serum or blood plasma. The blood separation gel comprises the following components: proportion regulator chlorcosane, organic gelling agent dibenzylidene sorbitol, thixotropic agent nano silica, viscosity regulator polyisobutene and the like. The preparation method comprises the following steps: adding polyisobutene, chlorcosane and dibenzylidene sorbitol in an planetary mixer, heating to 120 DEG C and then fully stirring and mixing; fully dissolving and evenly stirring the components and then cooling to less than 60 DEG C; adding nano silica; decompressing, vacuumizing, stirring and evenly mixing, and cooling to room temperature, so as to obtain the blood separation gel. According to the invention, the physical characteristic of the blood separation gel is obviously improved; and the blood separation gel prepared by the method provided by the invention can bear gamma rays in conventional sterilization amount, and is suitable for the environment which requires precise blood detection.

Description

[Technical field] [0001] The invention relates to the technical field of the manufacture of separation glue for blood collection equipment, in particular to a blood separation glue for blood collection containers and a preparation method thereof. [Background technique] [0002] The blood samples used by medical institutions for clinical testing are generally obtained by collecting blood from human veins, arteries or peripherals (finger tips, heels or earlobes). The types of blood samples are divided into whole blood, serum and plasma. Among them, serum or plasma is obtained by centrifugation after collection of blood samples. Such samples are mainly used for clinical test items such as clinical biochemical indicators, immunological indicators, coagulation function analysis, and nucleic acid detection. The collection of blood samples generally uses vacuum blood collection tubes or other non-vacuum collection containers. After blood collection, serum or plasma samples are sepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D17/02G01N35/00
Inventor 朱德新李健
Owner SHANGHAI KEHUADIAGNOSITIC MEDICAL PRODS
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