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Medicinal composition containing meropenem

A technology of meropenem and composition, which is applied in the field of medicine, can solve problems such as poor fluidity of direct filling, achieve stable product quality, large loss, and solve the effects of poor stability

Active Publication Date: 2012-02-01
瀚晖制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The purpose of the present invention is to provide a pharmaceutical composition containing meropenem, which can overcome the deficiencies of the prior art and effectively solve the problems of poor fluidity of direct filling of meropenem

Method used

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  • Medicinal composition containing meropenem
  • Medicinal composition containing meropenem
  • Medicinal composition containing meropenem

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Meropenem injections are prepared in 1,000 vials, of which:

[0082] Meropenem 250g

[0083] Lactose 250g

[0084] Preparation Process:

[0085] 1) Preparation: micronize meropenem to a particle size of 1-20 μm, and set aside;

[0086] 2) Mixing: Mix the prescribed amount of meropenem and lactose evenly with a high-efficiency mixer;

[0087] 3) Central control: carry out intermediate product inspection and calculate the loading range;

[0088] 4) Filling: Adjust the filling volume range of the filling machine and fill them in antibiotic bottles respectively;

[0089] 5) stopper;

[0090] 6) Gland;

[0091] 7) Light inspection: check for visible foreign matter;

[0092] 8) Packaging and storage.

Embodiment 2

[0094] Meropenem injections are prepared in 1,000 vials, of which:

[0095] Meropenem 500g

[0096] Lactose 500g

[0097] Preparation process: with embodiment 1.

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Abstract

The invention belongs to the technical field of medicines, and discloses a medicinal composition containing meropenem. The medicinal composition consists of a raw material meropenem and auxiliary materials, wherein the raw material meropenem is micronized meropenem. On the basis of further studying the physical and chemical properties of meropenem, research personnel surprisingly discovers that after the meropenem with a certain grain size is prepared by micronization, and lactose with a larger grain size is added, so that the meropenem is uniformly adsorbed to the surfaces of the lactose particles. The prepared preparation has the advantages of uniform quality and good stability. The meropenem medicinal composition has simple prescription and excellent stability, and is suitable for long-term storage and industrial large-scale production.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition containing meropenem. Background technique [0002] Meropenem is a variety developed by Sumitomo Co., Ltd. of Japan. It was launched in January 1995 under the trade name "Merrem" (美平), and it was jointly developed with AstraZeneca Pharmaceuticals. It was first launched in June 1996. Due to the carbapenem with a methyl group in the first position of the chemical structure of meropenem, it is stable to renal dehydropeptidase and does not need to be combined with enzyme inhibitors. The antibacterial spectrum and antibacterial effect are similar to imipenem, and have certain post-antibiotic effects. Meropenem is a very broad range of injectable antibiotics used to treat a number of different infections, including meningitis and pneumonia. It is a beta-lactam antibiotic that falls under the class of carbapenems. Unlike subampenem, meropenem is more stable to the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/407A61K47/26A61P31/04
Inventor 张昊
Owner 瀚晖制药有限公司
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