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Whitening Chinese medicinal composition

A composition and whitening technology, which can be used in pharmaceutical combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., and can solve problems such as poor stability, high price, and strong cytotoxicity.

Inactive Publication Date: 2012-04-18
SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the whitening agents used in cosmetics at home and abroad are mainly hydroquinone, kojic acid, fruit acid, arbutin and vitamin C derivatives, etc., some of which have disadvantages such as strong cytotoxicity, weak skin permeability, poor stability or high price.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Prescription: sea red bean 100g, Angelica dahurica 600g, cotyledon 600g, cherry leaf 600g, jasmine 300g (equivalent to 1:6:6:6:3).

[0058] Preparation method: take the above five Chinese herbal medicines, pulverize them, mix them evenly, add 20 times the total mass of water, soak at 60-70°C for 5 hours, separate the medicinal liquid, concentrate, spray dry, and pulverize to obtain 380g.

[0059] Whitening effect test: Take the composition of the present invention, make 0.5, 1, and 10 mg / mL with deionized water respectively, and label it as low, medium, and high dose groups. The test method refers to Test Example 1, and the test results (see Table 3) It shows that the composition of the present invention has strong whitening effect.

[0060] Table 3 Effect of the composition of the present invention on tyrosinase and melanin.

[0061] 　 Tyrosinase inhibition rate (%) Melanin synthesis inhibition rate (%) low dose group 54.4±0.3 44.3±0.6 Middle ...

Embodiment 2

[0063] Prescription: 300g sea red beans, 400g Angelica dahurica, 400g cotyledon leaves, 400g cherry leaves, 100g jasmine flowers (equivalent to 3:4:4:4:1).

[0064] Preparation method: take the above five Chinese herbal medicines, pulverize them, mix them evenly, add 20 times the total mass of water, soak at 60-70°C for 5 hours, separate the medicinal liquid, concentrate, spray dry, and pulverize to obtain 279g.

[0065] Whitening effect test: Take the composition of the present invention, make 0.5, 1, and 10 mg / mL with deionized water respectively, and label it as low, medium, and high dose groups. The test method refers to Test Example 1, and the test results (see Table 3) It shows that the composition of the present invention has strong whitening effect.

[0066] Table 4 Effect of the composition of the present invention on tyrosinase and melanin.

[0067] 　 Tyrosinase inhibition rate (%) Melanin synthesis inhibition rate (%) low dose group 52.3±0.5 42....

Embodiment 3

[0069] Prescription: sea red bean 300g, Angelica dahurica 400g, cotyledon 600g, cherry leaf 600g, jasmine 300g (equivalent to 3:4:6:6:3).

[0070] Preparation method: take the above five Chinese herbal medicines, pulverize them, mix them evenly, add 20 times the total mass of water, soak at 60-70°C for 5 hours, separate the medicinal liquid, concentrate, spray dry, and pulverize to obtain 383g.

[0071] Whitening effect test: Take the composition of the present invention, make 0.5, 1, and 10 mg / mL with deionized water respectively, and label it as low, medium, and high dose groups. The test method refers to Test Example 1, and the test results (see Table 3) It shows that the composition of the present invention has strong whitening effect.

[0072] Table 5 Effect of the composition of the present invention on tyrosinase and melanin.

[0073] 　 Tyrosinase inhibition rate (%) Melanin synthesis inhibition rate (%) low dose group 52.3±0.4 42.3±0.6 Middle ...

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Abstract

The invention relates to a whitening Chinese medicinal composition, which is characterized by comprising the following Chinese medicinal materials in part by mass: 1 to 3 parts of circassian bean, 4 to 6 parts of angelica dahurica, 4 to 6 parts of euphorbia lathyris leaf, 4 to 6 parts of cherry leaf and 1 to 3 parts of jasmine flowers. The whitening Chinese medicinal composition is prepared by a method comprising: grinding the five Chinese medicinal materials, uniformly mixing the five Chinese medicinal materials, adding water in an amount which is 20 times the total mass of the five Chinese medicinal materials, soaking at 60 to 70 DEG C for 5 hours, separating medicinal liquid, concentrating, spray-drying and grinding.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with whitening effect. Background technique [0002] With the development of society and the improvement of living standards, cosmetics have become an indispensable part of people's lives. At the same time, people have higher and higher requirements for the quality and performance of cosmetics. [0003] Skin color is determined by three factors: the content and distribution of various pigments in the skin, the content of oxyhemoglobin and reduced hemoglobin in the blood of the skin, the thickness of the skin and the scattering of light on the skin surface. Among them, melanin produced by melanocytes contained in the skin is the main factor that determines skin color, and tyrosinase is the key enzyme for synthesizing melanin. Therefore, inhibiting tyrosinase activity and thereby inhibiting the production of melanin is the ult...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K8/97A61P17/00A61Q19/02
Inventor 王峰王琳张发成
Owner SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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