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Extract for Relinqing Granule, as well as preparation method and application of same

An extract, water extraction technology, applied in the direction of antipyretics, drug combinations, pharmaceutical formulations, etc., to achieve the effect of prolonging the incubation time

Active Publication Date: 2012-07-04
GUIZHOU WARMEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relevant pharmacological studies are rare, and there are only a few reports by Ren Guangyou et al.

Method used

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  • Extract for Relinqing Granule, as well as preparation method and application of same

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0054] Preparation Example 1: Water Extract of Polygonum cephalum

[0055] Take 10Kg of the dry aboveground part of Polygonum cephalum, wash it with water, add 10 times the amount of water (W / W), soak for 1 hour, heat and boil for 1 hour, filter, add 6 times the amount of water to the filter residue, boil for 1 hour, filter, and combine The filtrate, when the filtrate was concentrated to 20°C, the relative density reached 1.3, and the concentrated solution was spray-dried to obtain 1.03Kg of dry fine powder.

preparation example 2

[0056] Preparation example 2: preparation of the extract of the present invention

[0057] Get 0.5Kg of dry fine powder (about 100 orders) obtained by the method of Preparation Example 1, and use 8 times (W / W) 82% ethanol to divide and extract ultrasonically twice, each time for 0.5 hours, filter, combine the filtrates, reclaim ethanol, and the residue is reduced Press and dry to obtain dry matter 0.047Kg, and this extract is used as the reagent in the part of the test in the following test examples.

preparation example 2a

[0058] Preparation example 2a: preparation of the extract of the present invention

[0059] In addition, with reference to the method of Preparation Example 2 above, extract with 6 times (W / W) 82% ethanol, 10 times (W / W) 82% ethanol respectively and ultrasonic treatment 2 times for 5 hours each time, the yield of the extract is the same as Preparation example 2 is basically identical; Gained extract is carried out following test example part test equally again, the result shows and the biological activity of extraction gained with 8 times (W / W) 82% ethanol extraction of preparation example 2 is basically identical (difference less than 10%), showing that under the condition of the same concentration of extract, extraction conditions such as the amount of extract and alcohol treatment time have no effect on the activity of the extract.

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Abstract

The invention relates to an extract for Relinqing Granule as well as a preparation method and an application of the extract, and particularly relates to an extract of Polygonum capitatum which serves as a raw material of Relinqing Granule, as well as the preparation method and the application of the extract. The Polygonum capitatum extract is substantially prepared by the following steps: (1), boiling fresh or dried aerial parts of Polygonum capitatum in water, filtering, and concentrating and drying the filtrate; and (2), extracting the dried product obtained in the step (1) with 75% to 85% ethanol, filtering, and concentrating and drying the filtrate, to obtain the Polygonum capitatum extract. The Polygonum capitatum extract has the beneficial effects shown as the description.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and is used as a raw material for preparing traditional Chinese medicine Relinqing granules, which is the extract of the medicinal material Polygonum cephalum. Specifically, the present invention relates to the extract of Relinqing granule and its preparation method and application. More specifically, the present invention relates to the raw material used for preparing Relinqing granules, that is, the extract of Polygonum cephalosporin, its preparation method and use. Background technique [0002] Polygonum capitatum Buch-Ham ex D.Don is a perennial herbaceous plant of the genus Polygonum. It has the effects of clearing heat and dampness, diuresis and treating stranguria, and has a significant effect in clinically treating urinary system infections. The Chinese patent medicine preparation "Relinqing Granule" made from it was included in the National Essential Drug List in 2002 and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P7/10A61P13/00A61P31/00A61P13/04A61P13/12A61P39/02A61P31/04A61P29/00A61P13/08
Inventor 梁斌万金志刘培庆张丽艳李孟林陈欣霞谢宇唐靖雯
Owner GUIZHOU WARMEN PHARMA
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