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Preparation method of compound sodium chloride-potassium chloride infusion solution

A technology of compound sodium chloride and potassium chloride, which is applied in the fields of active ingredients of alkali/alkaline earth metal chlorides, drug delivery, and pharmaceutical formulations, etc.

Inactive Publication Date: 2012-07-11
SICHUAN QILI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Potassium chloride is all injections, or diluted with 5% glucose injection for intravenous infusion, and there is no report of making it into an infusion directly

Method used

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Embodiment Construction

[0023] The invention provides a method for preparing an electrolyte replenishing drug, which is an infusion solution made of sodium chloride and potassium chloride as active ingredients, and each 100ml infusion solution contains 0.05-0.33g potassium chloride and 0.7-1.1 sodium.

[0024] In order to adapt to clinical application, three specifications of infusion solution are provided:

[0025] 1. Each 100ml infusion contains 0.11g of potassium chloride and 0.9g of sodium chloride;

[0026] 2. Each 100ml infusion solution contains 0.22g potassium chloride and 0.9g sodium chloride;

[0027] 3. Each 100ml infusion contains 0.30g of potassium chloride and 0.9g of sodium chloride.

[0028] The preparation method of above-mentioned transfusion is:

[0029] A, take potassium chloride and sodium chloride by recipe quantity;

[0030] B. Add an appropriate amount of water for injection (about 1 / 10 of the total volume of water for injection) to fully dissolve, and add water for inject...

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Abstract

The invention relates to the field of pharmacy and especially relates to a preparation method of a compound sodium chloride-potassium chloride infusion solution. The invention aims at providing a preparation method of an electrolyte supplement and the electrolyte supplement is the compound sodium chloride-potassium chloride infusion solution containing active components of sodium chloride and potassium chloride. Based on a prescribed dose, each 100ml of the compound sodium chloride-potassium chloride infusion solution contains 0.05 to 0.33g of potassium chloride and 0.7 to 1.1g of sodium chloride. The compound sodium chloride-potassium chloride infusion solution is applied by intravenous injection and is suitable for patients having severe hypokalemia or patients unable to take oral medicines. A potassium supplement dose, potassium concentration and a potassium supplement speed of the compound sodium chloride-potassium chloride infusion solution can be set according to clinical conditions, serum potassium concentration and improvement of a potassium deficiency graph of an electrocardiogram.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a preparation method of compound sodium chloride and potassium chloride infusion. Background technique [0002] Potassium is the main cation in the cell, and its concentration is 150-160mmol / L, while the main cation outside the cell is sodium ion, and the serum potassium concentration is only 3.5-5.0mmol / L. The body mainly relies on Na on the cell membrane + -K + ATPase to maintain intracellular and extracellular K + 、Na + Concentration difference. The acid-base balance in the body has an impact on potassium metabolism, such as H in acidosis + Into the cell, in order to maintain the potential difference in the cell, K + Released out of cells, causing or aggravating hyperkalemia. Metabolic disorders will also affect the acid-base balance. Normal intracellular and intracellular potassium ion concentrations and concentration differences are closely related to certain functions of cell...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P3/12A61P9/06A61J3/00
Inventor 毛兴荣杜宗涛刘嘉徐沉思花蕾文娟
Owner SICHUAN QILI PHARM CO LTD
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