New application of arginine

A technology of arginine and topical drugs, applied in the field of arginine, can solve the problems of exacerbating the damage of body tissues, achieve the effects of reducing metabolic burden, promoting synthesis, and reducing pain

Inactive Publication Date: 2012-07-25
智刚
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although both iNOS and cNOS can participate in various inflammatory response

Method used

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  • New application of arginine
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  • New application of arginine

Examples

Experimental program
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Example Embodiment

[0049] Example 1. Experimental results of the effects of topical arginine on wound healing and scarring

[0050] 20 6-week-old Wistar rats, weighing 220-260 grams. Randomly divided into 2 groups. There were 10 rats in the control group and the treatment group. For the observation of the effect of arginine on wound healing, and for the observation of the effect on the formation of scar tissue. Phenobarbital 50 mg / kg body weight, intraperitoneal injection. After 3-5 minutes of anesthesia, the median skin of the back of the rat was dehaired. After being wiped and disinfected with iodine and alcohol, under aseptic conditions, an incision of 10 mm in length and 1 mm in depth (up to the muscle layer) was cut. The rats in the control group were covered with sterile dressings, and the wounds in the experimental group were sprinkled with 0.1 g of L-serum. Cover with a sterile dressing after the amino acid powder.

[0051] 1. The effect of arginine on wound healing:

[0052] After...

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Abstract

The invention discloses new application of arginine, which is the application of arginine or a pharmaceutically acceptable salt, an ester or a mixture of the salt and the ester in preparing topical pharmaceutic preparations with at least one of the following effects: (1) treating and/or facilitating wound healing, and (2) reducing scar formation. Results in pharmacodynamics experiments show that the external use of L-arginine can remarkably facilitate trauma healing of rat skin as well as reduce the area of a wound scar. Arginine not only can be used for treatment and healing of traumas but also can be used for other skin diseases, including a pressure ulcer (bedsore), skin injuries caused by dermatitis, scald, burn and the like.

Description

technical field [0001] The invention relates to a new application of arginine. Background technique [0002] 1. L-arginine background [0003] L-arginine [L-Arginine; abbreviation L-Arg; symbol R, scientific name: 2-amino-5-guanidino-pentanoic acid (S)-2-Amino-5-guanidinopentanoic acid] is a guanidino-containing The aliphatic basic amino acids are positively charged and alpha polar. L-arginine is involved in protein synthesis, and the codons in messenger ribonucleic acid (mRNA) are CGU, CGC, CGA, CGG, AGA, and AGG. In animals, arginine is a semi-essential or conditionally essential amino acid according to the developmental stage and individual physical conditions (for example, the human body cannot synthesize arginine in infants and young children; increased arginine requirements). Arginine was first isolated in 1886 from a lupine seed extract by Swiss chemist Ernst Schultze. D-Arginine has not been found in nature. L-arginine is widely found in animal and plant foods....

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P17/02
Inventor 智刚张卫国
Owner 智刚
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