41 results about "Wound scar" patented technology

The invention relates to a prosthesis that can be implanted in the centre of wall wound scarring. The inventive prosthesis, which is intended for use in abdominal surgery, is provided with a geometric shape in the form of sheets that converge in dihedral angles. The sheets or planes are made from a synthetic biotolerated material in porous form with large pores. One of said planes is inserted into the centre of the scarring between the two aponeurotic surfaces to be joined. The other plane(s) of the prosthesis, which is perpendicular to the aforementioned plane, is arranged so as to overlap the aponeurotic edges of the edge of the section. The proliferation obtained around the prosthesis, in the scarring centre and close thereto, provides stress resistance greater than that obtained in standard closures, thereby greatly reducing the risk of hernias caused by a badly healed wound.

The present invention provides a complementary three-step dermabrasion system that provides treatment for skin conditions such as acne scars, wound scars, and other visually unappealing skin disfigurements, which constitutes the following, (1) Dermal Resurfacing with an adhesive composition, (2) Dermal Polishing with a polishing composition, and (3) Dermal Regeneration with a collagen-building and cell-proliferative composition.

The present invention provides a complementary three-step dermabrasion system that provides treatment for skin conditions such as acne scars, wound scars, and other visually unappealing skin disfigurements, which constitutes the following, (1) Dermal Resurfacing with an adhesive composition, (2) Dermal Polishing with a polishing composition, and (3) Dermal Regeneration with a collagen-building and cell-proliferative composition.

Skin remodeling is stimulated at the site of blemished skin using an ionic metal-peptide complex to diminish or remove the skin imperfection. The blemish can be a scar, especially surgical or wound scars, acne scars, keloid scars, and the like, or a skin tag, callus, benign skin mole, stretch marks, facial keratosis, thickened sunspots of the skin, or a vitiligo spot. The peptide-ionic metal complex is comprised of an ionic metal selected from copper(II), tin(II), tin(IV), and zinc(II), and salts thereof, and the peptide component can be a hydrolysis of casein, collagen, elastin, meat products, silk protein, or soybean protein, or a chemically synthesized dipeptide, tripeptide, tetrapeptide or the like which complexes with the ionic metal.

The invention discloses a preparation method of an antibacterial repairing type medical non-woven fabric. The preparation method is characterized by including: (1) opening: cleaning blend fibers in bacteria-free water for 2-3 times, and heating for opening; (2) combing to form a net: oscillating the blend fibers by ultrasonic waves with frequencies of 40 kHz and 25kHz, and settling to obtain a blend fiber net; (3) atomized water spraying: using pressurized atomized water to spray the front side and the reverse side of the blend fiber net; (4) drying: drying the blend fiber net in a low temperature after being sprayed by the atomized water; (5) preparing a bamboo fiber layer: preparing the dried blend fiber net into a bamboo fiber net layer according to the steps from (1) to (4); laminating by heat sealing: overlaying a tea fiber net layer with the bamboo fiber net layer, and adding medicament powder prior to laminating. The preparation method has the advantages that the prepared antibacterial repairing type medical non-woven fabric is uniform in thickness, high in stretchability, long in sterilizing effect lasting time and capable of healing a wound quickly and removing wound scars after being used.

The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.

The invention discloses a pure natural ointment for treating scalds and burns. The ointment is prepared through the following steps: preparing egg yolk oil, and preparing the ointment. The pure natural ointment makes up for the deficiencies in the prior art, is simple to prepare, and has substantial curative effects on scalds and burns, children's diaper rash, various types of dermatitis, and body surface ulcers. The ointment is a pure natural raw material, and a result of fifty years of clinic verification shows that the clinic cure rate and the effective rate of the pure natural ointment on patients with I and II grade burns and scalds and parts of patients with III grade burns and scalds respectively are 100%, and the pure natural ointment has the advantages of substantial effects, no wound scars and no untoward effects.

A surface suture device for skin wound has two supporting tapes arranged at both side of wound and a basic band with multiple sets of C-shaped suture thread guiders with C-shaped hole for limiting the suture thread to pass through it. Its advantages are uniform suture force and small residual scar.

The invention discloses application of a lavender oil formula preparation to skin scars. The application comprises the following steps: I, selecting materials; II, preparing a lavender oil formula preparation; III, performing mouse testing; IV, performing observation, and acquiring indexes; V, performing data comparison. By rubbing skin with lavender oil, a skin scar can be prevented; after a scalded part of a mouse is rubbed with the lavender oil, slight inflammation together with slight edema can be resulted, the wound at skin lesion can be clean at the seventh day, a medium amount of granulation tissue can be observed without exudation, the skin lesion is clean without crusta at the twenty-eighth day, the wound is completely healed, and hair grows out; with external application of the lavender oil, the level of an anti-inflammatory factor IL-10 in mouse serum can be increased, the inflammation of wounds can be relieved, expression of TGF-beta 1 can be remarkably improved, the activity of fibroblast can be improved, the ratio of type I / II procollagen can be adjusted, wound scars can be inhibited, and in addition, scar tissue can be repaired.

The invention discloses a preparation method of an antibacterial repairing type medical non-woven fabric. The preparation method is characterized by including: (1) opening: cleaning blend fibers in bacteria-free water for 2-3 times, and heating for opening; (2) combing to form a net: oscillating the blend fibers by ultrasonic waves with frequencies of 40 kHz and 25kHz, and settling to obtain a blend fiber net; (3) atomized water spraying: using pressurized atomized water to spray the front side and the reverse side of the blend fiber net; (4) drying: drying the blend fiber net in a low temperature after being sprayed by the atomized water; (5) preparing a bamboo fiber layer: preparing the dried blend fiber net into a bamboo fiber net layer according to the steps from (1) to (4); laminating by heat sealing: overlaying a tea fiber net layer with the bamboo fiber net layer, and adding medicament powder prior to laminating. The preparation method has the advantages that the prepared antibacterial repairing type medical non-woven fabric is uniform in thickness, high in stretchability, long in sterilizing effect lasting time and capable of healing a wound quickly and removing wound scars after being used.

A non-human animal model, method, spring, and kit for testing agents for treating wound scarring. The non-human test animal has a wound in a skin surface thereof, the wound having a perimeter edge; and a garter spring attached to the skin surface of the test animal in a position outside of the perimeter edge of the wound. The garter spring optionally has one or more bands for constricting the force exerted by the coil of the garter spring.

The present invention provides methods for preventing or treating infections, especially bacterial infections, by administering selective inhibitors of ATP production to inhibit glycolytic enzymes, such as glyceraldehyde 3-phosphate dehydrogenase (GAPDH). As such, the present invention further provides methods for preventing or treating inflammation and sepsis associated with infections, as well as increased wound healing and decreased wound scarring.

The invention discloses a care solution for nursing after hemorrhoids resection. The care solution is characterized by being prepared form the following medicinal materials in parts by weight: 12-15 parts of keel, 8-12 parts of oiltea camellia flower, 8-12 parts of lysimachia hypericoides hemsl, 8-12 parts of folium cycas, 12-15 parts of Japanese beauty-berry, 8-12 parts of gynura divaricata, 12-15 parts of hyperforin perforatum, 18-20 parts of conespike flemingia leaves, 8-12 parts of common cockscomb leaves, 12-15 parts of abroma angusta, 12-15 parts of semi-pinnated brake herb, 8-12 parts of longstamen loosestrife herb, 8-12 parts of elsholtzia blanda benth, 15-18 parts of rheum lidjiangense, 15-18 parts of henry hemsleya root and 15-18 parts of ligustrum sinense. According to the liquid medicine prepared by the formula disclosed by the invention, local hemodynamic disorders can be effectively improved; the contraction state of ani sphincter is relieved; the pain is relieved; tissue regeneration and wound healing of an incision are promoted; and wound scars are reduced.

The invention belongs to the technical field of biomedical materials, and discloses light-controlled liquefied hydrogel for inhibiting wound scar formation and a preparation method and application thereof.The light-controlled liquefied hydrogel is prepared from 6-18 parts of PVA hydrogel, 3-9 parts of borax boric acid buffer solution and 1-3 parts of PDA (at) CeO2-SAB nano-particle suspension.The hydrogel has the advantages that light-controlled liquefaction can be achieved, and the hydrogel can be applied to wound scar formation. The material has the characteristics of uniform particle size, accurate drug release, inhibition of CD36 expression, good biocompatibility, biodegradability and the like, can be used for infected wounds, and provides a novel, simple and effective material for wound inflammation inhibition and scar repair resistance treatment.

The invention discloses a hederacoside C deglycosylation derivative and a preparation method and application thereof.The hederacoside C deglycosylation derivative is prepared from hederacoside C through specific glycosidase hydrolysis, different products can be flexibly regulated and enriched on the basis of selectivity of different glycosidase to glucosidic bonds and glycosyl sites, the preparation method is simple, reaction conditions are mild, and the hederacoside C deglycosylation derivative is suitable for industrial production. The method is suitable for large-scale mass production. The hederacoside C deglycosyl derivative does not show obvious cytotoxicity to human immortalized keratinocytes, has the effect of promoting cell proliferation and the activity of promoting cell migration, and can obviously inhibit LPS (lipopolysaccharide)-induced cell apoptosis. Besides, the partial hederacoside C deglycosyl derivatives can reduce inflammatory factor level rise caused by wounds, remarkably promote wound healing and reduce formation of wound scars, and have good application prospects in preparation of drugs or skin care products for promoting wound repair.

The invention discloses a scald powder, which is composed of powdery raw materials vitamin B2, chloramphenicol and dexamethasone, and the weight ratio among the components is 1-4:2-5:1-3. In order to improve the anti-inflammatory effect, 1-3 parts by weight of powdery raw material sulfadiazine is also added. The medicine of the invention is an external medicine, and the preparation method is simple, and the raw materials of each component are crushed and mixed. The medicine of the present invention has the advantages of fast recovery of poisonous water for treating burns and scalds, strong ability of dispelling poisons, and rapid growth of flesh and skin. For small-area scalds and burns, it can be cured after two times of medication; for large-area scalds and burns, after two to three times of medication, the poisonous water will no longer flow, and the wound will scab. . The medicine of the present invention has an effective rate of 100% in treating various types of burns and scalds, a cure rate of 100%, no side effects, no scratches on the flesh, no scars, unblocked pores and intact skin after recovery, and is effective in treating bruises, bruises, and sores. Same effect.

The utility model discloses an intramedullary needle for treating fracture and convenient to hold, which is provided with a treatment section and a holding section for operating and holding, and a positioning structure for holding and positioning is further arranged on the holding section. The intramedullary needle conforms to tubular bone biological fixation, the treatment section can be effectively prevented from rotating in the surgical treatment operation process through the holding section, the penetration depth and path of the treatment section can be further accurately controlled, the treatment accuracy is improved, and the treatment duration is shortened. When the intramedullary needle is used in the treatment process of metacarpal bone fracture, further damage to fracture local hematoma and periosteum can be avoided through closed reduction, blood supply of sclerotin is protected, and fracture healing is facilitated. The intramedullary needle is small in trauma, small in wound scar and beneficial to attractiveness; intramedullary fixation retains the minimally invasive characteristic of kirschner wire fixation, and the fixing effect is more stable and lasting than that of a kirschner wire, and the articular surface is not damaged.

The invention relates to a formula of a traditional Chinese medicine for treating frostbite. The traditional Chinese medicine comprises 37-41g of rhizoma coptidis from Sichuan of China, 25-31g of phellodendron, 39-46g of garden burnet, 42-47g of Chinese gall, 20-30g of potato, 250-300g of honey and 200-250g of Vaseline. Through use of the traditional Chinese medicine for 5-10min, bleeding and a pain of a wound are stopped. Through use of the traditional Chinese medicine for about 1 week, frostbite can be cured. The traditional Chinese medicine can effectively prevent and control wound infection and cross infection, has no adverse side effect, and avoids wound scar after wound healing.

The present invention is concerned with a composition and in vitro method for generating a desired cell type and / or tissue type from hair follicular stem cells. The composition and in vitro method are particularly suitable for generating an autologous desired cell type and / or tissue type. Furthermore, the composition and method are especially efficient and suitable for use in the context of cosmetic cell and / or tissue transplantation in recipient areas of a subject experiencing cell and / or tissue loss caused by, for example, a wound, scar, burn injury, tissue degeneration, and aging. The composition and in vitro method are also suitable to circumvent complications related to infections and / or immune rejection of a cosmetic cell and / or tissue implant or graft.

Skin remodeling is stimulated at the site of blemished skin using an ionic metal-peptide complex to diminish or remove the skin imperfection. The blemish can be a scar, especially surgical or wound scars, acne scars, keloid scars, and the like, or a skin tag, callus, benign skin mole, stretch marks, facial keratosis, thickened sunspots of the skin, or a vitiligo spot. The peptide-ionic metal complex is comprised of an ionic metal selected from copper(II), tin(II), tin(IV), and zinc(II), and salts thereof, and the peptide component can be a hydrolysis of casein, collagen, elastin, meat products, silk protein, or soybean protein, or a chemically synthesized dipeptide, tripeptide, tetrapeptide or the like which complexes with the ionic metal.

The invention discloses a preparation method of a composition for inhibiting wound cicatrix healing, comprising the following steps: (1) weighing L-selenium-methylselenocysteine ​​and transparent uric acid, and measure the ultrapure water according to the ratio, and dissolve the weighed L-selenium-methylselenocysteine ​​in the ultrapure water, stir, shear, and vibrate with an ultrasonic mixer Shake or vortex until L-selenium-methylselenocysteine ​​is completely dissolved in ultrapure water, then add the weighed hyaluronic acid, and swell at room temperature for 1-2 days to obtain the composition stock solution; ( 2) Under sterile conditions, pass the composition stock solution through a 0.22 μm microporous membrane to sterilize, subpackage under sterile conditions after sterilization, and store at 2-8°C to obtain the antibacterial Composition for wound cicatrix healing. The composition for inhibiting wound cicatrix healing prepared by the invention can effectively reduce wound cicatrix healing, and can reduce the pigmentation of the wound site in the wound shaping stage.

The invention discloses functional sponge for promoting wound healing and reducing wound scar formation as well as a preparation method and application of the functional sponge. The method comprises the following steps: dissolving hyaluronic acid in water with the pH value of 4.5-5.5, and stirring to obtain a hyaluronic acid glue solution; adding EDC and NHS, carrying out a stirring reaction in a dark place, then adding the chitosan oligosaccharide-europium complex, continuing the reaction, injecting a reaction solution into a mold, and continuing the reaction in a shaking table to obtain a cross-linked hyaluronic acid gel; freezing and drying to obtain the hyaluronic acid / chitosan oligosaccharide-europium functional sponge, namely the functional sponge for promoting wound healing and reducing wound scar formation. The method is mild in experimental condition and simple and convenient in step, the chitosan oligosaccharide-europium complex is used as a cross-linking agent, chitosan oligosaccharide with an anti-inflammatory effect and europium element with a vascularization promoting function are introduced at the same time, and the obtained HA-CE is obvious in anti-oxidation, anti-inflammatory, vascularization promoting and fibrosis reducing effects and has a good application prospect.

The invention discloses a dressing for promoting wound healing. The dressing is prepared from the following raw materials: 3-15 percent of bioactive glass, 0.5-5 percent of nicotinamide, 0.01-1 percent of lyophilizing thrombin powder, 1-60 percent of glycerinum and 1-50 percent of gelatin. According to the dressing for promoting wound healing and a method for preparing functional cavernosum by applying the dressing, the dressing for promoting wound healing is fixed in a functional cavernous body to perfectly solve the medical problem that functional cavernosum is difficult to promote healing of wounds which are difficult to heal, has the advantages of promoting tissue regeneration, inducing epithelialization, reducing wound scars and the like, can be used for effectively stopping bleeding,adsorbing fluid oozed from a wound and providing a wet and transparent environment to a wound, is favorable to wound healing, can perfectly solve the problem of replacing skin-grafting for managementof wounds which cannot perform autologous healing, and can achieve the effect of promoting healing wounds which are difficult to heal after directly acting on the wounds.

This invention belongs to the field of biomedical materials technology and discloses a photocontrolled liquefaction hydrogel that inhibits wound scar formation, its preparation method, and its application. The photocontrolled liquefaction hydrogel is composed of the following raw materials: 6-18 parts PVA hydrogel, 3-9 parts borax-boric acid buffer solution, and 1-3 parts PDA@CeO2-SAB nanoparticle suspension. The hydrogel of this invention has the characteristics of photocontrolled liquefaction, precise drug release, inhibition of CD36 expression, good biocompatibility, and biodegradability. It can be used for infected wounds, providing a new, simple, and effective material for inhibiting wound inflammation and promoting scar repair.

The present invention is directed to topical skin adhesive formulations and kits for decreasing wound scarring comprising a rapidly curable two part liquid silicone formulation comprising a mixture of: Part A which comprises at least one vinyl terminated polydimethyl silicone base polymer, fumed silica particles, and a platinum catalyst capable of working at 20-40° C., Part B which comprises at least one vinyl terminated polydimethyl silicone base polymer and fumed silica particles, a cross-linker, a chain extender, and a medicant comprising verteporfin.

The invention discloses an amniotic membrane biological preparation and a preparation method thereof. The amniotic membrane biological preparation adopts the human and animal decellularized amniotic membrane covered with a platelet-rich factor plasma preparation, freeze-dried and irradiated, and stored in low-temperature refrigeration, and is used for repairing clinical skin damage treat. The amniotic membrane biological preparation can significantly improve the healing time of the wound and reduce the scar formation of the wound, and is an industrializable biological preparation with great clinical application prospects.

The present invention is directed to topical skin adhesive formulations and kits for decreasing wound scarring comprising a rapidly curable two part liquid silicone formulation comprising a mixture of: Part A which comprises at least one vinyl terminated polydimethyl silicone base polymer, fumed silica particles, and a platinum catalyst capable of working at 20- 40oC, Part B which comprises at least one vinyl terminated polydimethyl silicone base polymer and fumed silica particles, a cross-linker, a chain extender, and a medicant comprising verteporfin.

A system for reduced scarring of wounds; said system comprising: means (1) for creating an enclosed volume (3) over a wound site (2). The system further comprises: means (6, 10, 11, 12) for actively reducing the oxygen concentration within the enclosed volume at the surface of the wound to a first oxygen concentration level while maintaining an environment within the enclosed volume which is healthy for wound healing, means (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14) for ensuring that the oxygen concentration of the gas composition of the gas within the enclosed volume at the surface of the wound is maintained below a second oxygen concentration level and above a third oxygen concentration level, and where said system is arranged such that said first, second and third oxygen concentration levels are between 1 and 16 volume percent.

A non-human animal model, method, spring, and kit for testing agents for treating wound scarring. The non-human test animal has a wound in a skin surface thereof, the wound having a perimeter edge; and a garter spring attached to the skin surface of the test animal in a position outside of the perimeter edge of the wound. The garter spring optionally has one or more bands for constricting the force exerted by the coil of the garter spring.