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A preparation method of a composition for inhibiting wound cicatrix healing

A composition and scar technology, which can be used in drug combinations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of lack of skin, harmless scar removal products, etc., and reduce pigmentation. , inhibiting the proliferation of pathological scar fibroids, reducing the effect of wound scar healing

Active Publication Date: 2021-07-27
河南希百康健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is a lack of scar removal products that can effectively remove scars and are harmless to the skin

Method used

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  • A preparation method of a composition for inhibiting wound cicatrix healing
  • A preparation method of a composition for inhibiting wound cicatrix healing
  • A preparation method of a composition for inhibiting wound cicatrix healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] The preparation method of the composition for inhibiting wound cicatrix healing comprises the following steps:

[0072](1) Weigh 10mg L-selenium-methylselenocysteine ​​and 3g hyaluronic acid, and measure 500mL ultrapure water, and weigh the L-selenium-methylselenocysteine Dissolve in the measured ultrapure water to obtain the L-selenium-methylselenocysteine ​​aqueous solution to be stirred, and stir and shear the L-selenium-methylselenocysteine ​​aqueous solution to be stirred by an ultrasonic mixer Cut, shake or vortex until L-selenium-methylselenocysteine ​​is completely dissolved in ultrapure water to obtain an aqueous solution of L-selenium-methylselenocysteine, and then weigh the transparent Hyaluronic acid is added to an aqueous solution of L-selenium-methylselenocysteine, and the composition stock solution is obtained after swelling at room temperature for 1-2 days;

[0073] (2) Under sterile conditions, pass the stock solution of the composition prepared in ste...

Embodiment 2

[0076] The preparation method of the composition for inhibiting wound cicatrix healing comprises the following steps:

[0077] (1) Weigh 5mg L-selenium-methylselenocysteine ​​and 3g hyaluronic acid, and measure 500mL ultrapure water, and weigh the L-selenium-methylselenocysteine Dissolve in the measured ultrapure water to obtain the L-selenium-methylselenocysteine ​​aqueous solution to be stirred, and stir and shear the L-selenium-methylselenocysteine ​​aqueous solution to be stirred by an ultrasonic mixer Cut, shake or vortex until L-selenium-methylselenocysteine ​​is completely dissolved in ultrapure water to obtain an aqueous solution of L-selenium-methylselenocysteine, and then weigh the transparent Hyaluronic acid is added to an aqueous solution of L-selenium-methylselenocysteine, and the composition stock solution is obtained after swelling at room temperature for 1-2 days;

[0078] (2) Under sterile conditions, pass the stock solution of the composition prepared in ste...

Embodiment 3

[0081] The preparation method of the composition for inhibiting wound cicatrix healing comprises the following steps:

[0082] (1) Weigh 3mg L-selenium-methylselenocysteine ​​and 3g hyaluronic acid, and measure 500mL ultrapure water, and weigh the L-selenium-methylselenocysteine Dissolve in the measured ultrapure water to obtain the L-selenium-methylselenocysteine ​​aqueous solution to be stirred, and stir and shear the L-selenium-methylselenocysteine ​​aqueous solution to be stirred by an ultrasonic mixer Cut, shake or vortex until L-selenium-methylselenocysteine ​​is completely dissolved in ultrapure water to obtain an aqueous solution of L-selenium-methylselenocysteine, and then weigh the transparent Hyaluronic acid is added to an aqueous solution of L-selenium-methylselenocysteine, and the composition stock solution is obtained after swelling at room temperature for 1-2 days;

[0083] (2) Under sterile conditions, pass the stock solution of the composition prepared in ste...

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Abstract

The invention discloses a preparation method of a composition for inhibiting wound cicatrix healing, comprising the following steps: (1) weighing L-selenium-methylselenocysteine ​​and transparent uric acid, and measure the ultrapure water according to the ratio, and dissolve the weighed L-selenium-methylselenocysteine ​​in the ultrapure water, stir, shear, and vibrate with an ultrasonic mixer Shake or vortex until L-selenium-methylselenocysteine ​​is completely dissolved in ultrapure water, then add the weighed hyaluronic acid, and swell at room temperature for 1-2 days to obtain the composition stock solution; ( 2) Under sterile conditions, pass the composition stock solution through a 0.22 μm microporous membrane to sterilize, subpackage under sterile conditions after sterilization, and store at 2-8°C to obtain the antibacterial Composition for wound cicatrix healing. The composition for inhibiting wound cicatrix healing prepared by the invention can effectively reduce wound cicatrix healing, and can reduce the pigmentation of the wound site in the wound shaping stage.

Description

technical field [0001] The invention belongs to the technical field of wound scar repair, and in particular relates to a preparation method of a composition for inhibiting wound scar healing. Background technique [0002] Scar refers to the appearance, morphology and histopathological changes of normal skin tissue caused by trauma. Its formation is due to the severe damage of human skin and soft tissue, which cannot be completely repaired normally by itself, and is replaced by fibrous tissue, leaving a scar that affects both function and appearance. Abnormal and unsound organization. Scars bother most people's normal study and life, especially when the scars are exposed, it will seriously affect people's self-esteem and self-confidence. The current treatment methods are basically performed in two ways: surgical repair and drug softening. Surgical repair is generally to flatten the scar that is higher than the normal skin, and for the sunken scar, the method of paving the s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/198A61K47/36A61P17/02
CPCA61K9/0014A61K31/198A61K47/36A61P17/02A61K2300/00
Inventor 张继业李清清司佩茹杨显伟王梦涵莫菲马佳王阳李霁宇
Owner 河南希百康健康产业有限公司
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