Method for preparing multipurpose isoionic gold nanoparticle film
A technology of gold nanoparticles and plasma, applied in the field of material chemistry, can solve the problems of insufficient research and achieve the effect of regular membrane structure surface
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[0032] (1) Synthesis of DNA-modified gold nanoparticles
[0033] Preparation of chloroauric acid aqueous solution: Dissolve 1 g of chloroauric acid in 500 mL of double-distilled water once to prepare a 5 mM solution. The gold nanoparticles were prepared by reducing chloroauric acid with trisodium citrate. The 12-C DNA and 12-G DNA used in the present invention were purchased from Shanghai Sangon Bioengineering Co., Ltd., China, and purified by high performance liquid phase. All glass instruments were soaked in aqua regia, washed with ultrapure water, and dried for later use.
[0034] Synthesis of DNA-modified gold nanoparticles:
[0035] a. 1.9mL of Milli-Q ultrapure water, 0.1mL of HAuCl 4 Add the solution (concentration 5mM) into the reaction glass bottle and mix well at 37.0°C;
[0036] b1. Add 20 μL of 50 μM 12-C sequence DNA to a portion of the mixed system obtained in step a, and stir and mix at 37.0 °C for 15 min;
[0037] b2. Add 20 μL of 50 μM 12-G sequence DNA t...
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