Method for identifying key proteins based on characteristics of structural domain

A recognition method, protein technology, applied in special data processing applications, instruments, electrical digital data processing, etc., to achieve the effect of avoiding manpower and material resources
CN102841985AActive Publication Date: 2012-12-26CENT SOUTH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CENT SOUTH UNIV
Publication Date
2012-12-26

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Abstract

The invention discloses a method for identifying key proteins based on characteristics of a structural domain. For all proteins of species, the method comprises the following steps of: obtaining structural domain information through using a database or carrying out analysis of protein sequences, counting the frequency of occurrence of each structural domain type in the proteins on the basis of the structural domain information, and calculating the weight of each protein according to the statistical result, wherein the bigger is the weight, the more possibility of the protein is to form the key protein. The method is simple and effective, is only based on the structural domain information of the protein and does not rely on the network information of protein interactions and the like, so that the huge amount of manpower and material resources consumed in biological experiments can be avoided. Compared with a random method, the method provided by the invention can be used for accurately identifying key proteins.
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Description

technical field

[0001] The invention belongs to the field of systems biology and relates to a method for identifying key proteins based on structural domain characteristics. Background technique

[0002] Protein is an essential component of all cell and tissue structures, and the most important material basis for life activities. Not every protein in a cell is equally important, but different proteins have different importance to life activities. Usually those proteins that cause the loss of relevant biological functions after being deleted and cause the organism to fail to survive or cause disease are called key proteins. The identification of key proteins can provide valuable information for biology and medicine at the system level, especially in disease diagnosis and treatment, drug target design, and determination of the minimum genome (that is, including all key genes of a species) in synthetic biology. important application prospects.

[0003] Currently, there are t...

Claims

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