Preparation technique and production method for SHIZAO decoction in novel integrative dosage form

A production method and new dosage form technology, which is applied in the field of preparation of Shizaotang integrated new dosage form, to achieve the effect of wide target distribution and strong slow and controlled release performance

Inactive Publication Date: 2013-01-02
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic and foreign databases were used to search for novelties, and the following conclusions were drawn based on the reading, analysis and comparison of domestic and foreign literature: the innovation of the project of "developing new integrated dosage forms of nano-drugs with combined technology": 1) the use of nano-scale traditional Chinese medicine rich in trace elements Nanospheres, nanocapsules, polymer micelles, and solid ester nanoparticles of different particle sizes are prepared with different drug carriers such as powder, drug monomer, effective part, effective part group, traditional Chinese medicine extract, decoction concentrate, etc. , magnetic nanoparticles, immune nanoparticles, nanoemulsions, suspensions, vesicles, dru

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0057] The composition of the raw materials used to make the active ingredients is——

[0058] Daphne 1.5 parts, Euphorbia 1.5 parts, Gansui 1.5 parts, Jujube 10 parts.

[0059] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report.

Embodiment 2

[0061] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0062] The composition of the raw materials used to make the active ingredients is——

[0063] Daphne 1.5 parts, Euphorbia 1.5 parts, Gansui 1.5 parts, Jujube 10 parts.

[0064] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant steriliza...

Embodiment 3

[0066] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0067] The composition of the raw materials used to make the active ingredients is——

[0068] Daphne 1.5 parts, Euphorbia 1.5 parts, Gansui 1.5 parts, Jujube 10 parts.

[0069] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 12-72 hours. The application site: neck, chest, back, abdomen, legs, sole...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention relates to a preparation technique and a production method for SHIZAO decoction in a novel integrative dosage form. The raw materials of effective components of the SHIZAO decoction include genkwa flower 1.5 parts, knoxia root 1.5 parts, kansui root 1.5 parts, and jujube 10 parts. The production method includes processes of supersonic airstream grinding, extraction with alcohol and water, ultrasonic grinding extraction, water decoction concentrating, supersonic spray drying, nano-grinding, high-pressure homogenization, and preparation of nanoparticles. The invention makes good use of merits of multi-synergism and multi-targeting of complex nano-carrier technology, reduces production cost by mass production, improves product quality, and improves targeting and sustained-controlled release properties of drugs. The SHIZAO decoction in the novel integrative dosage form is suitable for oral and topical administration, can be administered in four time periods according to midnight-noon ebb-flow and human body qi and blood flow rules, and can be prepared into films or transdermal agents to be attached on different parts of human body according to the midnight-noon ebb-flow and human body qi and blood flow rules to be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Shizao Decoction, and also relates to a preparation technology of a new integrated dosage form of Shizao Decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/83A61K9/00A61P1/16A61P7/10A61P13/12A61P29/00A61P33/12
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap