Full-angle fluorescent molecular tomography imaging device based on rotating mirror

Abstract

The invention discloses a full-angle fluorescent molecular tomography imaging device and imaging method based on a rotating mirror, which belongs to the technical field of fluorescent molecular tomography imaging. The imaging device comprises a laser module, an optical galvanometer scanning module, a large planar reflector, a rotating mirror module and an optical probing module. The laser module is used to emit a circular collimated laser beam to the optical galvanometer scanning module, and the circular collimated laser beam is continuously reflected to the rotating module after being reflected to the large planar reflector through the optical galvanometer scanning module. The optical probing module is used to receive the reflective light of the rotating mirror module and image. The imaging device can tomography imaging distribution of fluorescent probes in vivo noninvasively for application such as cancer detection of small animals and medical therapeutic effect evaluation. Projections in multiple angles within 360 degrees can be obtained conveniently, and a large amount of detection data required by imaging are obtained, so that the imaging quality is improved.

Description

technical field [0001] The invention belongs to the technical field of fluorescence molecular tomography, and in particular relates to an all-angle fluorescence molecular tomography device and method based on a rotating mirror. Background technique [0002] Utilizing the high sensitivity and specificity of fluorescent probes, fluorescence in vivo imaging can observe biological activities at the molecular and cellular levels at the living level, and thus has received extensive attention and development. The traditional planar fluorescence imaging method is simple and easy to use, but limited by the diffuse propagation of photons in biological tissues, it is impossible to distinguish signals from different depths. The goal of fluorescence molecular tomography (FMT) is to accurately locate and quantify the distribution of fluorescent probes in small animals by detecting fluorescent photons from the surface, so it has become a research hotspot in recent years. In this method, o...

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Problems solved by technology

The former method will be limited in the continuous observation of fast biological phenomena, while the system implementation of the latter method will be very complicated

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