Polygalacic acid sperm-killing contraceptive suppository for external use and placing device

A polygallic acid and spermicidal technology, which is applied in the directions of suppository delivery, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as no research reports yet, and achieve a strong spermicidal effect.

Inactive Publication Date: 2013-04-03
邱毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After searching, there is no research report on spermicidal in vitro with telegalic acid

Method used

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  • Polygalacic acid sperm-killing contraceptive suppository for external use and placing device

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Embodiment Construction

[0015] The present invention will be further explained below.

[0016] 1. Preparation of Polygala acid extract:

[0017] Take Polygala sample, dry and pulverize, accurately weigh 5g powder, place it in a 300mL Erlenmeyer flask with stopper, add 70% methanol 150mL, soak for 1 hour, shake once every 15 minutes, heat to reflux for 5 hours, and evaporate the extract to dryness Add 200 mL of 10% hydrochloric acid solution to the residue, reflux in a boiling water bath for 2 hours, cool, filter and wash the precipitate with distilled water to neutrality, dissolve the precipitate with methanol and dilute to 200 mL to obtain a sample solution. After removing impurities, the precipitate is dried to obtain 500 mg of white powder. Take 5 mg of white powder, add 5 mL of methanol to dissolve, and use mobile phase to dissolve in a 10 mL volumetric flask. The sample solution is obtained, and the sample is injected for determination under chromatographic conditions.

[0018] Take another 5 mg of ...

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Abstract

The invention discloses a polygalacic acid sperm-killing contraceptive suppository for external use. The contraceptive suppository is characterized in that the active ingredient of the suppository is polygalacic acid diluent; the polygalacic acid diluent is different concentrations of physiological saline solution of polygalacic acid extracts; and the suppository is solid at normal temperature. When the contraceptive suppository is used, the contraceptive suppository is quickly dissolved in vaginas at body temperature, is in a semi-liquid state and can quickly kill sperms after being in contact with the sperms and deactivate the sperms, thus playing a role in contraception. The invention also discloses a matched placing device of the contraceptive suppository. The contraceptive suppository has a good contraceptive effect and can avoid unplanned pregnancy.

Description

Technical field [0001] The invention relates to a spermicidal contraceptive suppository for external use made by Polygalaic acid, belonging to the technical field of medicine, in particular to a spermicidal contraceptive suppository for external use Polygalaic acid and a placement device. Background technique [0002] Polygala is the dry root of Polygala. Polygala has a calm nature, bitter taste, and pungent. It has the effects of antitussive, expectorant, nourishing, stabilizing, detoxification, swelling, and tonic. Modern pharmacological research shows that some of its active ingredients also have antibacterial, hypoglycemic, immune enhancement and other activities. The applicant has used the Chinese herbal medicine Polygala extract to carry out in vitro sperm killing experiments, and the results showed that the sperm killing effect was significant. Within 0.5 minutes, it can kill the sperm of adults with fertility and normal activity and adult mouse sperm, and make the sperm ...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/58A61P15/18A61M31/00
Inventor 邱毅王磊光
Owner 邱毅
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