Antifungal capsule for dogs and cats

An antifungal and capsule technology, applied in antifungal agents, capsule delivery, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2013-05-08
QINGDAO VLAND BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Itraconazole is a broad-spectrum antifungal drug with great potential for development. At present, there is no itraconazole preparation on the market for pets. Fungal Itraconazole Capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] An antifungal capsule preparation for pets, the components and their weight and mass fractions are respectively (proportioned per 100g of raw materials):

[0012] Itraconazole 10 g

[0013] Starch 10 g

[0014] Lactose 60 g

[0015] Mannitol 10 g

[0016] 50% ethanol 5g

[0017] Microcrystalline Cellulose 5g

[0018] Preparation method: first pass the raw and auxiliary materials through a No. 6 (100 mesh) sieve, take the prescribed amount of itraconazole, starch, lactose, microcrystalline cellulose, and mannose, mix evenly, and wet granulate with 50% ethanol. After passing through the No. 2 (20 mesh) sieve, dry it in a drying oven at 50°C for 1 hour, take it out, let it cool, and screen No. 2 to No. 4 (20 mesh-60 mesh) granules, and make the obtained granules into capsules. The weight is 0.20g.

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PUM

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Abstract

The invention discloses an antifungal capsule for dogs and cats. The drug provided in the invention is the capsule prepared by making itraconazole into particles. Nearly 10 years of wide-range application of the drug itraconazole proves its efficacy and safety. With definite curative effects, the drug disclosed in the invention can effectively alleviate the development of dermatomycosis in dogs and cats.

Description

technical field [0001] The invention relates to an antifungal capsule for dogs and cats. It belongs to the field of veterinary medicine. Background technique [0002] Dermatomycosis of dogs and cats is a highly contagious zoonotic disease. The condition is stubborn and can cause cross-infection. With the increase in the number of companion animals such as dogs and cats, their dermatophytosis poses an increasing threat to human public health. [0003] Itraconazole is a synthetic triazole broad-spectrum antifungal drug that was launched in 1992. Its pharmacological action is: by affecting sterol 14α-demethylase, it effectively inhibits the biosynthesis of the main component of the fungal cell membrane (ergosterol), affects the permeability of the cell membrane, and causes the death of fungal cells to exert a strong antifungal effect. It is effective against dermatophytes, yeasts and some deep fungi. Itraconazole is a lipophilic and keratinophilic high-efficiency broad-sp...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/496A61P31/10
Inventor 郝智慧张瑞丽王艳玲
Owner QINGDAO VLAND BIOTECH INC
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