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Novel drug composition for curing hepatitis c virus

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problem of lower infection efficiency of hepatitis C virus

Inactive Publication Date: 2013-06-05
WATERSTONE PHARMA WUHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"If the NPC1L1 protein can be prevented from functioning, the infection efficiency of hepatitis C virus can be significantly reduced, and it is expected to develop new methods for the prevention and treatment of hepatitis C in the future.

Method used

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  • Novel drug composition for curing hepatitis c virus

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Embodiment Construction

[0030] In the present invention, when using ezetimibe and one or more anti-HCV drug compositions to treat viral hepatitis, ezetimibe and another anti-HCV drug can be administered together in one unit dose For example, the two or three are mixed to make unit dose tablet form, capsule form, or each exists in separate preparations, such as simply making etimibe tablet, bocepivir tablet Or ribavirin injection, the two are administered sequentially, and the administration is performed sequentially in this way, and the delayed administration of the second active ingredient should not reduce the synergistic effect between the combination of active ingredients. It should also be understood that ezetimibe, boceprevir or pharmaceutically acceptable derivatives thereof may be administered alone or in any combination, preferably simultaneously or in separate forms, regardless of simultaneous or sequential administration Administration is sequential, most preferably simultaneous.

[0031]...

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Abstract

The invention relates to a novel antiviral drug composition and a method for curing hepatitis c virus (HCV) infection by using the novel type antiviral drug composition. The novel antiviral drug composition comprises 1 - (4-fluorine phenyl) - (3R)- [3 - (4 - fluorine phenyl) - (3S) - hydroxypropyl] - (4S) - (4 - hydroxypropyl) - 2-acrylic amide (ezetimibe, structural formula presented as graph 1) or acceptable derivatives in pharmaceutic preparation thereof, and an HCV resisting drug which is a drug composition selected from one kind or multiple kinds of boceprecir (BOC), telaprevir (TVR), pegylated interferon alpha (PEG - IFN alpha), interferon (IFNO) and ribavirin.

Description

Technical field: [0001] The present invention relates to a novel antiviral pharmaceutical composition, which comprises 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]- (4S)-(4-hydroxyphenyl)-2-propanolactam (ezetimibe, Ezetimibe, structural formula see figure 1 ) or its pharmaceutically acceptable derivatives, and anti-HCV (hepatitis C virus) drugs are selected from Boceprevir (BOC), Telaprevir (TVR), long-acting interferon (PEG-IFNα ), interferon (IFNα), ribavirin (Ribavirin) one or more of the pharmaceutical composition and the method for treating HCV infection, belong to the field of pharmaceutical preparations. Background technique: [0002] Hepatitis C virus, referred to as hepatitis C, hepatitis C, is a kind of viral hepatitis caused by hepatitis C virus (Hepatitis C virus, HCV) infection, mainly through blood transfusion, acupuncture, drug abuse, etc., according to the World Health Organization Organization statistics show that the global HCV infecti...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K45/00A61K31/397A61K31/7056A61K38/21A61K38/06A61K31/497A61P1/16A61P31/14
Inventor 刘大鹏张发明
Owner WATERSTONE PHARMA WUHAN
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