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Novel medicinal application of fucoidan polysaccharide sulfate

A fucoidan and sulfate technology, which is applied in directions such as pharmaceutical combinations, medical preparations containing active ingredients, and applications

Active Publication Date: 2013-08-14
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no literature reporting the use of fucoidan sulfate in the treatment of diabetic retinopathy

Method used

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  • Novel medicinal application of fucoidan polysaccharide sulfate
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  • Novel medicinal application of fucoidan polysaccharide sulfate

Examples

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Embodiment 1

[0061] Example 1. Study on the Effect and Mechanism of Low Molecular Weight Fucoidan Sulfate on STZ-Induced Diabetic Mice Retinopathy

[0062] 1.1. Establishment and identification of STZ-induced diabetic mouse model

[0063] 1) Model establishment

[0064] In this experiment, conventional streptozotocin (STZ)-induced diabetic mouse model was used to study the effect and mechanism of Low Molecular Weight Fucoidan (LMWF) on diabetic retinopathy. Select C57BL / 6 male mice with a body weight of 18-20 g. After 3 days of adaptive feeding in the laboratory before modeling, fasting without water for 14 hours, intraperitoneal injection of streptozotocin-citrate buffer at a dose of 60 mg / kg body weight, and then giving 5% glucose aqueous solution to prevent hypoglycemia and Ensure sufficient water, and induce for 5 consecutive days. About 1 week later, the mice showed polydipsia and polyuria, and the random blood glucose and fasting 14-hour blood glucose were measured respectively, a...

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Abstract

The invention discloses a novel medicinal application of fucoidan polysaccharide sulfate. The application refers to the application of fucoidan polysaccharide sulfate in the preparation of the following products: 1), a product for preventing and / or treating diabetic retinopathy, 2), a product for inhibiting retinal new capillaries, 3), a product for inhibiting VEGF (vascular endothelial growth factor) protein expression of retina tissue, and 4), a product for inhibiting HIF-1 alpha (hypoxia inducible factor-1 alpha)) protein expression of retina tissue. Preferably, the fucoidan polysaccharide sulfate is LMWF with the weight-average molecular weight of 3KD to 30KD. The pharmacodynamic experiment proves that the LMWF has a function in improving the retinopathy of STZ (streptozocin) induced diabetes mellitus mouse; under the function, the function of the retina capillaries is improved and the ischemia and anoxic state in retina are improved, therefore the down-regulation of expression of VEGF and HIF-1alpha are related; because the molecular weight of the LMWF is relatively small, the fucoidan polysaccharide sulfate can be adsorbed after being taken orally, the side effect is less, and therefore, the fucoidan polysaccharide sulfate has latent application significance in preventing and treating retinopathy.

Description

technical field [0001] The invention relates to a new medicine application of fucoidan sulfate. Background technique [0002] Fucoidan sulfate is a kind of natural sulfated polysaccharide rich in fucose. It is currently reported that the substance has a variety of biological functions, such as anti-oxidation, anti-coagulation, anti-thrombosis, anti-proliferation, anti-adhesion, anti-viral effects and so on. [0003] Sulfated fucan polysaccharides (Fucans) are a class of anionic polysaccharides derived from marine organisms, most of which are derived from brown algae. Due to the different growth environments, regions, and species of algae, they show a variety of structures, but have a basic conservative structure. Fucoidan is the first polysaccharide isolated and extracted from sulfated Fucus. In 1913, Kylin was first obtained and named from brown algae. In the following decades, the extraction process of fucoidan sulfate was continuously optimized, and its various biologic...

Claims

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Application Information

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IPC IPC(8): A61K31/737A23L1/29A61P27/02A23L33/00
Inventor 罗大力杨文哲崔文通张全斌
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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