Borneol-containing compound preparation as well as preparation method and application thereof

A technology of compound preparation and borneol, which is applied in the field of traditional Chinese medicine compound preparation for the treatment of depression and its preparation, can solve the problems of easy relapse and narrow antidepressant spectrum, and achieve the effect of strict compatibility, no toxic side effects, and low price

Inactive Publication Date: 2014-07-16
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among the drugs for treating depression, chemical drugs have obvious effects, but the side effects of such drugs after long-term use are always worrying, such as the toxic side effects of tricyclic antidepressants on the heart, and the weight change and sexual function caused by other chemical drugs Obstacles have not been resolved, and there are also shortcomings such as narrow antidepressant spectrum and easy relapse. Therefore, traditional Chinese medicine and its prescriptions with mild effects and few side effects have attracted more and more attention.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Borneol-containing compound preparation as well as preparation method and application thereof
  • Borneol-containing compound preparation as well as preparation method and application thereof
  • Borneol-containing compound preparation as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Take 15g of Bupleurum, 15g of Citrus aurantium, 12g of Chuanxiong, 10g of Codonopsis, 10g of Atractylodes macrocephala, 12g of Poria cocos, 10g of Magnolia officinalis, 6g of Qing Pinellia, 20g of mother of pearl, 8g of August leaves, 2g of borneol, and 6g of licorice. First crush the mother-of-pearl, pass through a 60-mesh sieve, add 200ml of water, and fry for 20 minutes. 12 times the weight of the medicinal material, extracted twice with distilled water for 1 hour each time, filtered through gauze, combined the filtrates, concentrated under reduced pressure to an extract with a relative density of 1.15 at 65°C, added ethanol so that the volume percentage of the alcohol content reached 75%, Dry in vacuum at low temperature for 12 hours to obtain dry paste a; in addition, dissolve borneol with 10 times the amount of 70% ethanol, add β-cyclodextrin to distilled water at 40°C to make a saturated solution, and the weight of β-cyclodextrin is the weight of borneo...

Embodiment 2

[0018] Example 2: Take Bupleurum 17g, Citrus aurantium 17g, Rhizoma Chuanxiong 14g, Codonopsis 12g, Atractylodes macrocephala 12g, Poria cocos 14g, Magnolia officinalis 12g, Pinellia chinensis 7g, mother-of-pearl 25g, August phlegm 10g, borneol 3g, and licorice 8g. First crush the mother-of-pearl, pass through a 60-mesh sieve, add 250ml of water, and fry for 20 minutes. 12 times the weight of the medicinal material, extracted with distilled water for 3 times, each time for 2 hours, filtered through gauze, combined the filtrate, concentrated under reduced pressure to an extract with a relative density of 1.20 at 65°C, added ethanol to make the volume percentage of the alcohol content reach 85%, Dry in vacuum at low temperature for 12 hours to obtain dry paste a; in addition, dissolve borneol with 10 times the amount of 70% ethanol, add β-cyclodextrin to distilled water at 40°C to make a saturated solution, and the weight of β-cyclodextrin is the weight of borneol 7 times, under...

Embodiment 3

[0019] Example 3: Get Bupleurum bupleuri 13g, Citrus aurantium 13g, Rhizoma Chuanxiong 10g, Codonopsis 8g, Atractylodes macrocephala 8g, Poria cocos 10g, Magnolia officinalis 8g, Qing Pinellia 5g, mother of pearl 15g, August 6g, borneol 1g, licorice 4g, first Crush the mother-of-pearl, pass through a 60-mesh sieve, add 150ml of water, and fry for 20 minutes, then add Bupleurum, Aurantium, Chuanxiong, Codonopsis, Atractylodes macrocephala, Poria, Magnolia officinalis, Pinellia chinensis, August Zha, licorice, and medicinal materials Extract 12 times the weight of distilled water twice, each time for 1 hour, filter with gauze, combine the filtrates, concentrate under reduced pressure to an extract with a relative density of 1.15 at 65°C, add ethanol so that the volume percentage of the alcohol content reaches 75%, and store at low temperature Vacuum-dry for 12 hours to obtain dry paste a; in addition, dissolve borneol with 10 times the amount of 70% ethanol, add β-cyclodextrin to...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an application of a borneol-containing compound preparation in preparation of medicines for treating depression. The traditional Chinese medicine compound preparation is prepared from the following raw material medicines in parts by weight: 13-17 parts of radix bupleuri, 13-17 parts of immature bitter orange, 10-14 parts of Ligusticum wallichii, 8-12 parts of Codonopsis pilosula, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 10-14 parts of Poria cocos, 8-12 parts of Mangnolia officinalis, 5-7 parts of rhizoma pinelliae preparata, 15-25 parts of nacre mother of pearl, 6-10 parts of fiveleaf akebia fruit, 1-3 parts of borneol and 4-8 parts of liquorice. A preparation method is further disclosed. The pharmacological testing result shows that the preparation has the improving effect on behavioristics of depression, and the action is associated with factors which adjust related nerves in the brain. The preparation provided by the invention has the advantages that the process of the compound preparation is simple to control, the bioavailability is high, the effect is remarkable and the cost is low.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine preparation for treating depression and its preparation method and application. Background technique [0002] Depression is an affective disorder with persistent low mood as the main symptom, and it is the most common type of mental illness. Its pathogenesis is complex and related to various factors such as genetics, environment, and society. With the continuous development of society, the pressure and competition faced by people in daily life and work are increasing, and the incidence of depression is gradually increasing. is climbing rapidly. WHO predicts that by 2020 depression will rank second in the total burden of disease. In China, more than 26 million people suffer from depression, and about 10% to 15% of them die by suicide. Prevention and treatment of depression has become an important task at present. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8888A61K9/16A61P25/24A61K31/045A61K35/56A61K35/618
Inventor 喻斌阮鸣程海波方泰惠许惠琴卢金福
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap