Pharmaceutical composition used for preventing and controlling metabolic syndrome and application thereof

A technology for metabolic syndrome and composition, applied in the field of pharmaceutical compositions for preventing and treating metabolic syndrome, can solve the problem that there is no report on the combination of aliskiren and ligustrazine, and there is no literature report on the combination of aliskiren and ligustrazine for preventing and treating metabolic syndrome. and other problems, to achieve the effect of good systolic blood pressure and pulse pressure difference, reduced arterial pressure, and enhanced glucose tolerance

Active Publication Date: 2014-06-25
泰安泰山科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the combination of aliskiren and ligustrazine at home and abroad, and there is no literature report on the prevention and treatment of metabolic syndrome with aliskiren and ligustrazine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Effect of Aliskiren / Ligustrazine Phosphate on Rat Model of Metabolic Syndrome

[0021] Male Wistar rats, weighing 180-220g, were screened first, and the animals were selected as the animals for this study based on the criteria of rapid escape, screaming, vertical tail, panting, and difficulty in adapting to the stimulation of plantar electric shock and noise for the first time. Animals were housed individually in stimulation cages and fed a high-fat diet. Before starting the stimulation, the animals were fed normally for one week, and then the stimulation was started, twice a day, the stimulation intensity: 2 hours in the morning and 2 hours in the afternoon, and continuous stimulation for about 8 weeks. Glucose tolerance test was done after modeling. Oral Glucose Tolerance Test (OGTV): After fasting for 12 hours, the rats were fed with 50% glucose solution at a dose of 2.5g / kg, and blood was taken from the tail vein to detect the blood glucose value for 2 ho...

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PUM

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Abstract

The invention discloses a pharmaceutical composition used for preventing and controlling a metabolic syndrome and application thereof. Active components of the pharmaceutical composition comprise: (1) aliskiren or a pharmaceutically acceptable salt thereof; and (2) ligustrazine phosphate. The composition provided by the invention has same effects on reduction of blood pressure, blood fat, blood sugar and body weight as each active component of the composition does; compatible usage of the two active components enables the dosage of each individual component to be greatly reduced, so adverse reaction of aliskiren and drug risk of ligustrazine phosphate are substantially reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for preventing and treating metabolic syndrome and its application. Background technique [0002] Overweight or obesity, accompanied by a series of diseases such as hypertension, hyperlipidemia, hyperglycemia, atherosclerosis and hyperinsulinemia, this phenomenon is called metabolic syndrome in medicine. Metabolic syndrome is a common physical problem faced by the urban population. It can not only increase the risk of diabetes and cardiovascular and cerebrovascular diseases, but also increase the mortality of cardiovascular and cerebrovascular diseases. Metabolic syndrome is a polygenic, inherited disorder that is influenced by the environment. Its clinical feature is the combination of obesity, dyslipidemia, hyperglycemia and hypertension. And these four kinds of diseases are often "collusion", which is the "death quartet" of modern ur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4965A61P9/12A61P9/10A61P3/06A61P3/10A61P3/04A61K31/165
Inventor 于法周
Owner 泰安泰山科技有限公司
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