Applications of coumarin derivatives in preventing and curing serious brain diseases
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A disease and drug technology, applied in the field of medicine, can solve problems such as insufficient curative effect and side effects
Inactive Publication Date: 2013-12-18
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
View PDF1 Cites 12 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Although a wide variety of drugs are used clinically, their application is limited due to the existence or insufficient curative effect, or serious side effects
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0058] m.p.296-299℃; 1 H NMR (300MHz, DMSO-d 6 ):δ5.927(s,1H),5.710(s,1H),2.650-3.685(br,8H),2.650(s,3H),2.120(d,2H,J=4.6Hz),1.428(m, 1H),1.281(m,4H),0.853(t,6H,J=7.2Hz).HRMS Calcd.For C 20 h 29 N 2 o 4 (M+H + )361.2127;found361.2124.
[0062] m.p.262-265℃; 1 H NMR (300MHz, DMSO-d 6 ):δ10.421(s,1H),10.186(s,1H),8.441(s,1H),7.348(dd,2H,J=8.7Hz,J=1.5Hz),7.082(dd,2H,J= 8.7Hz, J=1.5Hz), 6.258(d, 1H, J=2.4Hz), 6.124(d, 1H, J=2.4Hz), 3.459(s, 1H), 2.779-4.400(br, 8H), 2.668 (s,3H),1.174(s,3H),1.151(s,3H);HRMS Calcd.For C 24 h 28 N 3 o 5 (M+H + ) 438.2029; found 438.2007.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses applications of coumarin compounds and salts thereof acceptable in pharmacy in preparation of drugs for preventing and curing brain diseases, especially for preventing or curing diseases related with neuron damage and neuron inflammation, and specifically for preventing or curing Parkinson's disease, Alzheimer's disease, cerebral ischemia, depression, and cerebral apoplexy.
Description
technical field [0001] The present invention relates to coumarin derivatives and a new medical application of such compounds, especially in the prevention and treatment of brain neurological and mental diseases such as stroke, dementia, Parkinson's disease and depression; field of medical technology. Background technique [0002] With the rapid development of modern society, the accelerated pace of life and work, coupled with the aging of the social population, major brain diseases, including neurological diseases and mental disorders (especially stroke, dementia, Parkinson, depression, etc.) Seriously endangering human health, it not only reduces the quality of life of patients, but also brings heavy economic burden to patients' families, which will also become a serious social problem. [0003] Modern medicine believes that the abnormal damage and loss of neurons is a common pathological feature of major brain diseases such as stroke, dementia, Parkinson, and depression. ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more