Polypeptide composition with skin activity

A polypeptide composition and composition technology, applied in the field of skin-active polypeptide compositions, can solve problems such as side effects, pain and infection

Active Publication Date: 2014-01-15
SHENZHEN WINKEY MEDICAL RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Active ingredients for anti-aging in cosmetics are mainly concentrated in some plant extracts before peptides, and small molecular compounds such as vitamin C are also used. In addition, many invasive methods are used to achieve anti-aging purposes, such as injection of botulinum toxin (Botox) can paralyze and relax the facial expression muscles to achieve the effect of rapid wrinkle removal, but it is accompanied by great risks such as infection, pain, facial paralysis caused by improper injection, etc. In addition, collagen or hyaluronic acid injections are also used to fill wrinkles, which also have the same effect. The risk of pain and infection, as well as the application of microneedles combined with epidermal growth factor (EGF) or fibroblast growth factor (BFGF), which mainly destroys the skin epidermis and then applies growth factors for repair, is also invasive The above-mentioned various invasive methods belong to the category of medical cosmetology, which have great destructive and side effects

Method used

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  • Polypeptide composition with skin activity
  • Polypeptide composition with skin activity
  • Polypeptide composition with skin activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Essence preparation of β-Ala-Pro-Dab-NHBzl and pal-KTTKS

[0029] Prescription (1kg essence):

[0030]

[0031] Preparation method: heat water to boil and cool down to 60-70°C, add Phenonip, stir to dissolve, and divide into two parts. Slowly add sodium hyaluronate to one portion with stirring at a constant temperature of 55°C to completely dissolve and fully swell. The other part was added with various polypeptide components, stirred and ultrasonically dissolved, and filtered with a 0.45um microporous membrane. Add the dissolved polypeptide, Lubar gum and glycerin into the sodium hyaluronate aqueous solution, stir to form a homogeneous solution, and adjust the pH value of the solution to about 5.5 with 15% triethanolamine solution. Packed separately, each bottle is 1kg.

Embodiment 2

[0033] β-Ala-Pro-Dab-NHBzl, Ac-EEMQRR-NH 2 , Tyr-D-Ala-Gly-Phe-Leu, pal-KTTKS, Pal-GHK, Pal-GQPR and Pal-VGVAPG essence preparation

[0034] Prescription (1 kg):

[0035]

[0036] Preparation method: Prescribed amount of Pal-VGVAPG is fully dispersed with HRE60 at 50°C, adding glycerin and Lubar gum, and ultrasonically dissolving. Heat the water to boil, when the temperature drops to 60-70°C, add the prescribed amount of Phenonip, stir to dissolve. Divide into two parts, one part is slowly added sodium hyaluronate under stirring at a constant temperature of 55°C to make it completely dispersed and fully swollen. The remaining polypeptides were added to the other part, stirred and ultrasonically dissolved, and filtered with a 0.45um microporous membrane. Add the dissolved polypeptide into the sodium hyaluronate aqueous solution, stir to form a uniform solution, and adjust the pH value of the solution to about 5.5 with 15% triethanolamine. Filter with a 180-mesh sieve, pa...

Embodiment 3

[0038] β-Ala-Pro-Dab-NHBzl, Ac-EEMQRR-NH 2 , Pal-KTTKS, Pal-GHK, Pal-GQPR and Pal-KVK lyophilized powder preparation

[0039] Prescription (per bottle):

[0040]

[0041] Preparation method: Take the prescribed amount of each polypeptide, mix and moisten it with Tween 20, add an appropriate amount of purified water, and dissolve it by ultrasonication. Take the prescribed amount of mannitol, add purified water to dissolve, and heat to 100 degrees Celsius for 30 minutes. Leave to cool to 50°C. Add the above-mentioned dissolved polypeptide into the mannitol aqueous solution, mix well, and filter with a microporous membrane of 0.22um. Packed into vials, the volume of each bottle is 1ml, freeze-dried for 24hr.

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Abstract

The invention discloses polypeptide composition with skin activity for the problems of various wrinkles and ageing of skin. The composition comprises a combination of polypeptides with argireline effects and polypeptides with effects of promoting the generation of skin proteins and improving the skin, wherein the concentrations of the polypeptides are all 0.01 ppm to 5,000 ppm. The composition provided by the invention can be used for quickly smoothening the wrinkles, reducing the wrinkle depth, promoting the generation of various skin matrix proteins and enabling the skin to be compact, elastic, full and smooth.

Description

technical field [0001] The present invention relates to the preparation of various dosage forms including essence, lotion, freeze-dried powder, cream, mask, etc. by adopting the method of compounding active cosmetic polypeptides, which are used to treat skin aging problems, including botulism by inhibiting the contraction of facial muscles Achieve the purpose of quickly removing wrinkles and promoting the production of various proteins in the skin to improve skin quality. Background technique [0002] The following description contains information that may be useful in understanding the present invention. It is not an admission that any information provided herein is prior art to the presently claimed invention or related applications, nor is any specific or implied disclosure referred to as prior art. [0003] 1. Peptide introduction; [0004] Regarding peptides, there is an accurate definition in biochemistry: natural active substances formed by covalently linking two or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61Q19/08
Inventor 丁文锋
Owner SHENZHEN WINKEY MEDICAL RES DEV
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