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Sanguisorba extract for treatment of AIDS (acquired immunodeficiency syndrome) and preparation method thereof

A technology of extract and HIV, which is applied in the field of Burnet extract and its preparation, can solve the problem that no effective method to cure AIDS has been found

Active Publication Date: 2014-02-12
陈建萍 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] AIDS has been spreading around the world at an alarming rate since it was first discovered in 1981, and humans still have not found an effective cure for AIDS

Method used

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  • Sanguisorba extract for treatment of AIDS (acquired immunodeficiency syndrome) and preparation method thereof
  • Sanguisorba extract for treatment of AIDS (acquired immunodeficiency syndrome) and preparation method thereof
  • Sanguisorba extract for treatment of AIDS (acquired immunodeficiency syndrome) and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Take 100 g of coarse powder of Burnet elata, decoct and extract twice with 10 times water (V / W), 1 hour each time, combine the two extracts, concentrate to dryness under reduced pressure, and obtain 13.7 g of Burnet burnet water extract.

Embodiment 2

[0042] 1000g of coarse powder of Burnet elata, ultrasonically extracted twice with 10 times the amount (V / W) of 60% ethanol, 1 hour each time, the two extracts were combined, concentrated under reduced pressure until no alcohol smell, and then washed with ethyl acetate Esters and n-butanol were extracted 3 times respectively to obtain 3 extracts with different polarities: ethyl acetate extract-I (ETOAC-I) 10.2g, n-butanol extract-I (BUOH-I) 18.4g and Aqueous residue (DW) 59.3g.

Embodiment 3

[0044] 100g coarse powder of Burnet elata, reflux extraction with 10 times the amount (V / W) of 60% ethanol twice, each time for 1 hour, combine the two extracts, concentrate under reduced pressure until no alcohol smell, and obtain 60% alcohol extract 12.5g; the ethanol extract was extracted 5 times with ethyl acetate, the combined extracts were recovered to dryness under reduced pressure, and the ethyl acetate extract-II (ETOAC-II) of Burnet was obtained.

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Abstract

The invention provide a sanguisorba extract for treatment of AIDS (acquired immunodeficiency syndrome) and a preparation method thereof, and the sanguisorba extract mainly comprises gallic acid, ellagic acid, hydrolysable tannin and condensed tannin. The sanguisorba extract has excellent inhibitory activity and low cytotoxicity to R5-tropic and X4-tropic AIDS viruses.

Description

technical field [0001] The invention relates to a Burnet eucalyptus extract and a preparation method thereof, in particular to a Burnet eucalyptus extract for treating AIDS and a preparation method thereof. Background technique [0002] Burnet is the dry root of Sanguisorba officinalis L. or Sanguisorba officinalis L.var.longifolia (Bert.) Yüet Li, a plant of the Rosaceae family. The Large Intestine Meridian has the effects of cooling blood to stop bleeding, detoxifying and suppressing sores. [0003] The research on the chemical constituents of Burnet mainly focuses on tannins, triterpenes and triterpene saponins, flavonoids and steroids, among which tannins, triterpenes and triterpene saponins have the highest content. Tannin is considered to be the material basis for its astringent and hemostatic effect. [0004] Tannins, also known as tannins, are a class of polyphenolic compounds with complex structures existing in plants. In 1920, K Frendenberg classified tannins in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/739A61P31/18
Inventor 陈建萍刘利陈志伟王冬梅杨得坡梁建国郑骁
Owner 陈建萍
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