Drug-loading degradable magnetic anastomat

A magnetic stapler and magnetic anastomosis technology, applied in the field of anastomosis structure, can solve the problems of too simple structure, easy infection, limitation, etc., and achieve the effects of promoting wound healing, reducing infection risk, and accelerating wound healing.

Inactive Publication Date: 2014-03-05
XI AN JIAOTONG UNIV
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on magnetic stapler has made great progress, but its structure is usually too simple, mainly including two magnetic rings, and the stapler is not easy to be discharged from the body after anastomosis. The repair of the anastomotic stoma in the crushing process relies solely on the patient's own internal regulation. The anastomotic operation is prone to infection, and the reconstruction of the anastomotic stoma takes a long time. The biocompatibility in the body during the magnet crushing process is poor, which limits its clinical application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug-loading degradable magnetic anastomat
  • Drug-loading degradable magnetic anastomat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] A drug-loaded degradable magnetic squeeze anastomat, involving magnet materials, degradable materials (such as PLGA, cellulose (BC), collagen-PGA, and hydroxyapatite-chitin, etc.) and drugs that promote the healing of anastomosis (including growth factors, vitamin C, prophylactic antibiotics, etc.) and other three materials, the structural unit of the stapler is a ring body divided into inner and outer layers, and several magnets are placed between the inner ring and the outer ring.

[0029] The inner ring is made of degradable materials. Its main function is to support the magnets in the early stage of anastomotic reconstruction and provide a suitable pressing force for the anastomosis. In the later stage of anastomotic reconstruction, it can be degraded into magnets and discharged to save space. Biodegradable materials can use biomaterials with certain strength and fast degradation speed according to performance requirements.

[0030] The outer ring is a mixture of de...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
sizeaaaaaaaaaa
sizeaaaaaaaaaa
sizeaaaaaaaaaa
Login to view more

Abstract

The invention provides a drug-loading degradable magnetic anastomat comprising two same structure units. Each structure unit comprises an annular body and a plurality of magnets. Each annular body is composed of an inner ring and an outer ring. The magnets are evenly arrayed between the inner rings and the outer rings along the circumferential directions of the annular bodies. The inner rings can be made of degradable materials, and the outer rings can be made of mixtures of drugs for simulating healing of anastomotic stomas and the degradable materials. The drug-loading degradable magnetic anastomat formed by the annular bodies with outer layers and inner layers and the magnets arrayed along circumferences, the inner rings can be made of the degradable materials, and the outer rings can be made of the mixtures of drugs for simulating healing of anastomotic stomas and the degradable materials, so that magnetic pressure anastomosing can be realized at the initial stage of tissue cavity anastomosing; the size of the magnetic anastomat decreases gradually along with degradation of the inner rings and the outer rings, and then the magnetic anastomat can be discharged out of the body successfully; drugs released during degradation of the outer rings leak to the peripheries of the anastomotic stomas, so that wound healing is accelerated, infection risks are reduced, and anastomosing cycle is shortened.

Description

technical field [0001] The invention relates to a biodegradable anastomotic structure, in particular to a drug-loaded degradable magnetic anastomat that can promote the regeneration of anastomotic cells. Background technique [0002] For severe hepatobiliary and intestinal diseases, surgical treatment such as gallbladder, part of gastrointestinal tract, partial hepatectomy or even liver transplantation is often required. The anastomotic reconstruction technique of surgical hollow organs is a basic operation in the process of operation. Requirements for anastomotic reconstruction include: simplicity and short operation time, good serosa coaptation, few anastomotic complications, and easy excretion of the stapler after anastomosis. At present, the research on magnetic stapler has made great progress, but its structure is usually too simple, mainly including two magnetic rings, and the stapler is not easy to be discharged from the body after anastomosis. The repair of the ana...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/115A61L31/16A61L31/06A61L31/04
CPCA61L31/042A61L31/044A61L31/047A61L31/06A61L31/148A61L31/16A61B17/155A61B2017/00004A61B17/1114A61B2017/1117A61B2017/1132A61B2017/00876
Inventor 刘亚雄虢宏昌马峰吕毅李涤尘胥光申
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products