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Aqueous ophthalmic composition

A composition and ophthalmology technology, applied in the direction of drug combination, drug delivery, medical preparations of non-active ingredients, etc., can solve the problems of defoaming time, antiseptic efficacy and photostability that are not yet clear and cannot be easily predicted. To achieve the effect of reducing the defoaming time

Active Publication Date: 2016-02-17
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the effects of adding sesame oil to aqueous ophthalmic compositions on defoaming time, preservative efficacy and photostability have not been clarified
In particular, the effect on aqueous ophthalmic compositions when these components and specific surfactants are added to the aqueous ophthalmic composition cannot be easily predicted

Method used

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  • Aqueous ophthalmic composition
  • Aqueous ophthalmic composition
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Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0218] According to the formulations shown in Table 10 and Table 11, eye drops (Preparation Examples 1 to 8), eye washes (Preparation Examples 9 and 10) and eye drops for soft contact lenses (Preparation Example 11) were prepared.

[0219] [Table 10-1]

[0220] Table 10

[0221] Unit: w / v%

[0222]

Preparation Example 1

Preparation example 2

Preparation example 3

Preparation Example 4

Preparation Example 5

Preparation Example 6

eye drops

eye drops

eye drops

eye drops

eye drops

eye drops

Polyoxyethylene castor oil 3

-

-

-

0.5

-

0.1

Polyoxyethylene castor oil 10

0.1

0.5

0.4

-

0.5

0.3

Polyoxyethylene castor oil 35

-

0.5

0.5

0.001

-

0.2

sesame oil

0.1

0.0025

0.05

0.05

0.1

0.05

ε-aminocaproic acid

-

-

-

3

-

-

berberine sulfate

0.05

0.05

-

...

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PUM

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Abstract

According to the aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil and (B) sesame oil, defoaming time is reduced, preservative efficacy is enhanced, and photostability is improved.

Description

technical field [0001] The present invention relates to an aqueous ophthalmic composition. More specifically, the present invention relates to an aqueous ophthalmic composition with reduced defoaming time, enhanced preservative efficacy and improved photostability. Background technique [0002] In the field of ophthalmology, solubilizers are added to various formulations. In particular, in aqueous ophthalmic compositions, various solubilizers are added to facilitate dissolution of bioactive components and additives and the like having relatively low water solubility. Surfactants can be exemplified as solubilizers used in the field of ophthalmology. It is known that polyoxyethylene castor oil is a nonionic surfactant, and adding it to an aqueous ophthalmic composition helps dissolve other components (Patent Document 1). [0003] Aqueous compositions containing surfactants are known to be prone to foaming, and foaming occurs when subjected to vibration or impact during prod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/44A61K9/107A61K47/04A61K47/34A61P27/02
CPCA61K9/0048A61K47/02A61K47/10A61K47/26A61K47/44A61P27/02
Inventor 中田温子松本江利
Owner ROHTO PHARM CO LTD
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