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Collutory with bacterial-resisting, inflammation-eliminating and deodorizing functions and preparation method and use of collutory

An antibacterial, anti-inflammatory and mouthwash technology, which is applied to medical preparations containing active ingredients, anti-inflammatory agents, local antibacterial agents, etc., can solve the problems of large side effects of western medicine, peeling of oral mucosa, and imbalance of bacterial flora, etc., and achieve good antibacterial effect Function, keeping breath fresh, good safety effect

Active Publication Date: 2014-06-18
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Most of the mouthwashes on the market are the combination of Chinese and Western medicines to prevent and treat oral diseases, and take Western medicines as the main functional components. Unfavorable and adverse drug reactions, severe cases may even cause flora imbalance, oral mucosa peeling and superimposed infection; and some oral care solutions containing Chinese herbal ingredients show their superiority in this respect

Method used

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  • Collutory with bacterial-resisting, inflammation-eliminating and deodorizing functions and preparation method and use of collutory
  • Collutory with bacterial-resisting, inflammation-eliminating and deodorizing functions and preparation method and use of collutory
  • Collutory with bacterial-resisting, inflammation-eliminating and deodorizing functions and preparation method and use of collutory

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 (percentage by weight)

[0021]a. Take the pomegranate peel and crush it into a coarse powder, add 10 times the concentration of 40% ethanol and soak it warmly. Crude drug 0.15-0.2g; the concentrated solution is passed through HPD300 macroporous resin column, adsorbed for 12 hours, first eluted with distilled water until the effluent is nearly colorless, then eluted with 2 times the column volume of 60% ethanol, and the alcohol-containing eluent is collected , reclaim ethanol, concentrate and dry under reduced pressure, pulverize, pass through 80 mesh sieves, and set aside;

[0022] b. Take 10% of roses and 10% of brocade lanterns, add 5 times the concentration of 65% ethanol to heat and reflux for extraction twice, each time for 2 hours, filter, combine the filtrate to recover ethanol under reduced pressure, and concentrate to a relative density of 1.05- 1.10 (temperature 60°C) solution, for later use;

[0023] c. Take 5% pomegranate peel polyphenol extr...

Embodiment 2

[0024] Embodiment 2 (percentage by weight)

[0025] a. Take the pomegranate peel and crush it into a coarse powder, add 15 times the concentration of 40% ethanol to warm soak, the temperature is 75 ℃, extract twice, each time for 2 hours, filter, the filtrate is decompressed to recover ethanol, and concentrate to the equivalent of Crude drug 0.15-0.2g; the concentrated solution is passed through HPD300 macroporous resin chromatography column, adsorbed for 12 hours, first eluted with distilled water until the effluent is nearly colorless, then eluted with 3 times the column volume of 60% ethanol, and the alcohol-containing eluent is collected , recover ethanol, concentrate and dry under reduced pressure, pulverize, pass through a 100-mesh sieve, and set aside;

[0026] b. Take 20% of roses and 20% of brocade lanterns, add 10 times the concentration of 70% ethanol to heat and reflux for extraction once, extract for 3 hours, filter, combine the filtrate to recover ethanol under r...

Embodiment 3

[0028] Embodiment 3 (percentage by weight)

[0029] a. Take pomegranate peel and crush it into coarse powder, add 20 times the concentration of 40% ethanol, extract three times at 80°C for 1.5 hours each time, filter, combine the filtrate to recover ethanol under reduced pressure, and concentrate to the equivalent per mL 0.15-0.2g of crude drug; add the concentrated solution to the treated HPD300 macroporous adsorption resin column, absorb for 6 hours, first wash with deionized water until the color of the effluent is light, and then use 4 times the column volume Eluted with 60% ethanol, collected eluent containing alcohol, recovered ethanol, concentrated under reduced pressure and dried in vacuum to dry extract, pulverized, passed through a 120 mesh sieve to obtain pomegranate peel polyphenol extract, and set aside;

[0030] b. Take 15% of roses and 20% of brocade lanterns, add 15 times the concentration of 75% ethanol to heat and reflux for extraction 3 times, each time for ...

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Abstract

The invention discloses a collutory with bacterial-resisting, inflammation-eliminating and deodorizing functions and a preparation method and use of the collutory. The collutory is prepared from principal raw materials such as a pomegranate bark extract, roses and calyx seu fructus physalis in combination with a humectant, a sweetening agent, a preservative and distilled water. The collutory can form an obstacle on the surfaces of the teeth due to joint effect of the effective components, so that bacteria are hardly attached to the surfaces of the teeth and bacteria attached to the surfaces of the teeth to cause bacterial plaque are reduced, thereby keeping the oral cavity clean and eliminating odor of the oral cavity. The collutory can be used for preventing or treating gingivitis, periodontitis, dental ulcers and oral and throat inflammations. Meanwhile, the collutory can eliminate ozostomia and maintain fresh breath, and not only can be used for adjuvant therapy of oral inflammations, but also can be used for daily oral health. The collutory used for a long time is free of any side effects. When in use, the product used not only facilitates movement of muscles around the oral cavity by means of the mouthwash movement, but also promotes the self-cleaning effect of the oral cavity, so that the collutory is the best option for maintaining oral hygiene and preventing oral infection.

Description

technical field [0001] The invention relates to an antibacterial, anti-inflammatory and deodorizing mouthwash and its preparation method and application, in particular to a liquid oral gargle with antibacterial, anti-inflammatory, deodorizing, easy to use and no toxic or side effects, its preparation method and application. Background technique [0002] The oral cavity is one of the ways for pathogenic microorganisms to invade the human body. The temperature, humidity and food residues in the oral cavity are suitable for the reproduction and growth of microorganisms. The interdental spaces and gingival grooves in the oral cavity are difficult to clean. These anatomical features are conducive to the growth of bacteria. Therefore, oral hygiene is very important to the health of the human body, especially for patients with high fever, postoperative disturbance of consciousness, and artificial respiration. Because they cannot eat orally, the secretion of saliva decreases, the mou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K36/81A61Q11/00A61P1/02A61P11/04A61P29/00A61P31/02
Inventor 阿吉艾克拜尔·艾萨罗玉琴来海中马依努尔·拜克力
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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