Luteolin chewable tablet and preparation method thereof

A technology of luteolin and chewable tablets, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of low drug bioavailability, poor water solubility and stability of luteolin Low-level problems, to achieve the effect of reducing mental burden, good bioavailability, and good taste

Inactive Publication Date: 2016-01-13
成都普瑞法科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs contain multiple active ingredients, and there is no single drug containing luteolin on the market.
[0003] The water solubility of luteolin is poor, and its stability is low, which leads to its low drug bioavailability

Method used

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  • Luteolin chewable tablet and preparation method thereof
  • Luteolin chewable tablet and preparation method thereof
  • Luteolin chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 5

[0062] Example 5 Preparation of luteolin chewable tablet of the present invention

[0063] Preparation of luteolin solid dispersion: accurately weigh a certain mass of luteolin in a small beaker, add a small amount of ethanol and heat appropriately to dissolve luteolin. Accurately weigh a certain mass of PEG4000, place it in an electric heating mantle and heat it until it melts, quickly pour the luteolin solution into the PEG4000 melt, wash the small beaker containing the luteolin solution several times with a small amount of ethanol, and pour it into the PEG4000 melt. in the oil bath at a constant temperature of 55°C and stirring for about 30 minutes to fully disperse the drug in the carrier, volatilize most of the ethanol, and place it on an ice-salt bath immediately. Freeze it in a -80°C refrigerator for 24 hours, take it out, dry it in a 40°C drying box for 24 hours, remove the residual solvent, and pulverize to obtain a yellowish powder, which is dried and stored for late...

Embodiment 6

[0065] Example 6 Preparation of luteolin chewable tablet of the present invention

[0066] The same method as Example 5, but the formula ratio is adjusted to luteolin solid dispersion (weight ratio of luteolin and PEG4000 is 1:2) 30g, mannitol 150g, xylitol 150g, vitamin C 10g, orange essence 1mL. Preparation of Luteolin Chewable Tablets

[0067] 30g of solid dispersions in Table 1 were respectively used, and the remaining auxiliary materials were: 150g of mannitol, 150g of xylitol, 10g of vitamin C, and 1mL of orange essence. Chewable tablets were made according to the method of Example 5, and the dissolution rate of each chewable tablet was measured respectively. The measurement results showed:

[0068] The performance of the chewable tablet made of luteolin and PEG4000 is better than that of other chewable tablets, especially the comprehensive performance (dissolution and stability) of the chewable tablet of luteolin and PEG4000 when the weight ratio of luteolin and PEG400...

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Abstract

The invention relates to a luteoloside chewing tablet and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The solved technical problem is to provide the luteoloside chewing tablet. The luteoloside chewing tablet is prepared from the following compositions in parts by weight: 3-9 parts of luteoloside solid dispersion, 28-35 parts of manitol, 1-3 parts of vitamin C, 0.3-1 part of a lubricant and 0.1-0.3 part of a flavoring agent. The luteoloside solid dispersion is prepared by uniformly mixing 1-3 parts by weight of luteoloside and 2-6 parts of PEG4000 and performing fusion.

Description

technical field [0001] The invention relates to a luteolin chewable tablet and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Luteolin is a natural flavonoid, which is widely distributed in plants, and also contains luteolin in a variety of medicines, such as Shuanghuanglian oral liquid, Qingyan lozenges, Kanggan capsules, etc. However, these drugs all contain a variety of active ingredients, and there is no single drug containing luteolin on the market. [0003] Luteolin has poor water solubility and low stability, resulting in low drug bioavailability. SUMMARY OF THE INVENTION [0004] The technical problem to be solved by the present invention is to provide a luteolin chewable tablet. [0005] The luteolin chewable tablet of the present invention is prepared from the following components in parts by weight: 3-9 parts of luteolin solid dispersion, 28-35 parts of xylitol, 28-35 parts of mannitol, 1-3 p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/7048A61K47/34A61P11/00A61P9/10A61P9/00A61P25/00
Inventor 张良蕾谢海峰胡云岭
Owner 成都普瑞法科技开发有限公司
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