Luteoloside chewing tablet and preparation method thereof

A technology of luteolin and chewable tablets, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of low stability, poor water solubility of luteolin, and drug bioavailability Low-level problems, to achieve good taste, good bioavailability, and reduce the burden on the heart

Inactive Publication Date: 2014-08-20
成都普瑞法科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs contain multiple active ingredients, and there is no single drug containing luteolin on the market.
[0003] The water solubility of luteolin is poor, and its stability is low, which leads to its low drug bioavailability

Method used

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  • Luteoloside chewing tablet and preparation method thereof
  • Luteoloside chewing tablet and preparation method thereof
  • Luteoloside chewing tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 5

[0062] Embodiment 5 Preparation of luteolin chewable tablets of the present invention

[0063] Preparation of luteolin solid dispersion: Accurately weigh a certain mass of luteolin into a small beaker, add a small amount of ethanol and heat appropriately to dissolve luteolin. Accurately weigh a certain amount of PEG4000, place it in an electric heating mantle and heat it until it melts, quickly pour the luteolin solution into the PEG4000 melt, wash the small beaker containing the luteolin solution several times with a small amount of ethanol, and pour it into the PEG4000 melt Heat and stir at a constant temperature of 55°C on an oil bath for about 30 minutes to fully disperse the drug in the carrier, evaporate most of the ethanol, and immediately place it on an ice-salt bath, wait for the mixture of luteolin and PEG4000 to cool and solidify rapidly, and then place Freeze in a -80°C refrigerator for 24 hours, take it out, dry in a 40°C drying oven for 24 hours to remove residua...

Embodiment 6

[0065] Example 6 Preparation of Luteolin Chewable Tablets of the Present Invention

[0066] The method is the same as in Example 5, but the formula ratio is adjusted to 30g of luteolin solid dispersion (the weight ratio of luteolin to PEG4000 is 1:2), 150g of mannitol, 150g of xylitol, 10g of vitamin C, and 1mL of orange essence. Luteolin Chewable Tablets Made

[0067] Use 30g of the solid dispersion in Table 1, and the remaining auxiliary materials are: 150g of mannitol, 150g of xylitol, 10g of vitamin C, and 1mL of orange essence. Chewable tablets were made according to the method of Example 5, and the dissolution rate of each chewable tablet was measured respectively, and the measurement results showed:

[0068] The performance of the chewable tablet made of luteolin and PEG4000 is better than that of other chewable tablets, especially the comprehensive performance (dissolution and stability) of the chewable tablet of luteolin when the weight ratio of luteolin and PEG4000 ...

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Abstract

The invention relates to a luteoloside chewing tablet and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The solved technical problem is to provide the luteoloside chewing tablet. The luteoloside chewing tablet is prepared from the following compositions in parts by weight: 3-9 parts of luteoloside solid dispersion, 28-35 parts of manitol, 1-3 parts of vitamin C, 0.3-1 part of a lubricant and 0.1-0.3 part of a flavoring agent. The luteoloside solid dispersion is prepared by uniformly mixing 1-3 parts by weight of luteoloside and 2-6 parts of PEG4000 and performing fusion.

Description

technical field [0001] The invention relates to luteolin chewable tablets and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Luteolin is a natural flavonoid that is widely distributed in plants. It is also contained in various medicines, such as Shuanghuanglian oral liquid, Qingyan buccal tablets, and Kanggan capsules. However, these drugs all contain multiple active ingredients, and there is no single drug containing luteolin on the market. [0003] The water solubility of luteolin is poor, and its stability is low, which leads to its low drug bioavailability. Contents of the invention [0004] The technical problem to be solved by the present invention is to provide a chewable luteolin tablet. [0005] The luteolin chewable tablet of the present invention is prepared from the following components in parts by weight: 3-9 parts of luteolin solid dispersion, 28-35 parts of xylitol, 28-35 parts of mannit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61K47/34A61P11/00A61P9/10A61P9/00A61P25/00
Inventor 张良蕾谢海峰胡云岭
Owner 成都普瑞法科技开发有限公司
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