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A kind of preparation method of three-dimensional cod liver oil emulsion

A three-dimensional cod-liver oil and emulsion technology, applied in the field of preparation of three-dimensional cod-liver oil emulsion, can solve problems such as vitamin C instability, inability to completely solve degradation problems, instability, etc., achieve low processing cost, mature preparation process route, and good taste Effect

Active Publication Date: 2016-08-17
QINGDAO DOUBLE WHALE PHARMA
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Problems solved by technology

[0002] The main components of three-dimensional cod liver oil emulsion are vitamins A, D, and C. Vitamins A and D are essential substances for human growth and development, especially for the development of fetuses and infants, the integrity of epithelial tissues, vision, blood calcium and phosphorus, and bones. It plays an important role in the growth and development of teeth and teeth. Vitamin C participates in the formation of antibodies, collagen and tissue repair in the body, as well as the metabolism of sugar, fat and protein, and maintains the integrity of blood vessels. Various diseases caused by deficiency, such as night blindness, xerophthalmia, corneal softening, rickets, rickets, etc.; traditionally, three-dimensional cod liver oil emulsion is an oil-in-water emulsifier, that is, an o / w emulsion. The main components of the product contain fat-soluble vitamins A, D and water-soluble vitamin C. Vitamin C is dissolved in the water phase of the emulsion. The following two methods are adopted: one is to refer to the production method of vitamin C injection, and the whole production process should be carried out in an anaerobic environment, and supplementary materials such as chelating agent and antioxidant are added, because the three-dimensional cod liver oil emulsion is an oral emulsion, and it is multi-dose packaging, so its processing and preparation process is difficult to achieve the whole process of anaerobic, the use of this strict control process can only alleviate the degradation of vitamin C, and can not completely solve the problem of degradation; the second is to make vitamin C into inclusion complexes, liposomes and other applications in solid preparations and semi-solid preparations, this inclusion compound is not suitable for emulsions

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  • A kind of preparation method of three-dimensional cod liver oil emulsion

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Embodiment 1

[0013] Embodiment 1: Preparation of a three-dimensional cod liver oil emulsion suitable for adults.

[0014] This embodiment prepares 1000 g of three-dimensional cod liver oil emulsion, and the content of each component is as follows: oil phase: 10 g of cod liver oil, 0.062 g of vitamin A, 0.163 mg of vitamin D, 652 g of soybean oil; emulsifier: 1.54 g of vitamin C; 5.235 g of soybean lecithin; The rest is purified water in the aqueous phase; 79g of absolute ethanol is required.

[0015] The preparation process of the present embodiment is:

[0016] (1) after the soybean lecithin of commercially available product is added in 79g absolute ethanol and stirred and dissolved evenly, be mixed with soybean lecithin solution;

[0017] (2) Put the vitamin C of the commercially available product through a 100 mesh sieve into a conventional boiling drying bed, and then spray the soybean lecithin solution prepared in step (1) into the drying bed in a boiling state, and control the tempe...

Embodiment 2

[0019] Embodiment 2: Preparation of a three-dimensional cod liver oil emulsion suitable for children.

[0020] The present embodiment makes three-dimensional cod liver oil emulsion 1000g, and its each component content is, oil phase: cod liver oil 10g, vitamin A0.03g, vitamin D0.338mg, soybean oil 652g; Emulsifier: vitamin C1.54g, soybean lecithin 5.235g; The rest is purified water in the aqueous phase; 79g of absolute ethanol is required.

[0021] The preparation process of the present embodiment is:

[0022] (1) adding soybean lecithin to dehydrated alcohol earlier, after stirring and dissolving, be mixed with soybean lecithin solution;

[0023] (2) Pass the vitamin C through a 100-mesh sieve, put it into a boiling drying bed, spray the soybean lecithin solution in a boiling state, and dry it at 45-55°C to prepare vitamin C soybean lecithin microcapsules;

[0024] (3) Dissolve cod liver oil, vitamin A, and vitamin D in soybean oil in sequence, then add vitamin C soybean le...

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Abstract

The invention belongs to the technical field of medicine preparation, and relates to a method for preparing a three-vitamin cod-liver oil emulsion by extracting the vitamin C to an emulsifying layer from a water phase of the emulsion. The preparing method includes the technical steps of preparing a soyabean lecithin solution, preparing phosphatide micro-capsules and emulsifying, wherein soyabean lecithin is added into absolute ethyl alcohol and completely dissolved through stirring to obtain a soyabean lecithin solution; the vitamin C is put into a boiling drying bed, and the soyabean lecithin solution is sprayed into the boiling drying bed to obtain vitamin C soyabean lecithin micro-capsules after drying; cod-liver oil, the vitamin A and the vitamin D are dissolved in soybean oil through mixing and stirring, the vitamin C soyabean lecithin micro-capsules and purified water are sequentially added and evenly stirred, and then reverse tangent emulsifying is carried out to obtain the three-vitamin cod-liver oil emulsion finished product. The preparing technology is mature in route, and the three-vitamin cod-liver oil emulsion is rich in nutrient, good in mouthfeel and taste, low in processing cost, safe and reliable.

Description

Technical field: [0001] The invention belongs to the technical field of medicine preparation, and relates to a technology for extracting vitamin C from an emulsion water phase into an emulsified layer for preparing a three-dimensional cod-liver oil emulsion, in particular to a novel preparation method of a three-dimensional cod-liver oil emulsion. Background technique: [0002] The main components of three-dimensional cod liver oil emulsion are vitamins A, D, and C. Vitamins A and D are essential substances for human growth and development, especially for the development of fetuses and infants, the integrity of epithelial tissues, vision, blood calcium and phosphorus, and bones. It plays an important role in the growth and development of teeth and teeth. Vitamin C participates in the formation of antibodies, collagen and tissue repair in the body, as well as the metabolism of sugar, fat and protein, and maintains the integrity of blood vessels. Various diseases caused by def...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/59A61K9/107A61K47/24A61P3/02A61P27/02A61P19/08A61K31/375A61K31/07
Inventor 耿仕霞倪志伟卢大峰杨珊珊白建宏
Owner QINGDAO DOUBLE WHALE PHARMA
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