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Prophylactic agent for squamous carcinoma, squamous carcinoma model anima, and method for producing said model animal

A squamous cell carcinoma and animal model technology, applied in dairy products, drug combinations, food preparation, etc., can solve problems such as unknown effect of Candida

Active Publication Date: 2014-09-03
MEIJI CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nothing is known about the effect on Candida infection

Method used

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  • Prophylactic agent for squamous carcinoma, squamous carcinoma model anima, and method for producing said model animal
  • Prophylactic agent for squamous carcinoma, squamous carcinoma model anima, and method for producing said model animal
  • Prophylactic agent for squamous carcinoma, squamous carcinoma model anima, and method for producing said model animal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] [Example 1] Establishment of disease model

[0064] Immediately after induction of diabetes with alloxan, human Candida albicans was experimentally administered to try to induce early inflammation and proliferative lesions.

[0065] To 10-week-old female WBN / Kob rats, alloxan (Sigma) was administered once through the tail vein at a dose of 40 mg / kg, and the state of diabetes was confirmed over 2 weeks. For animals without diabetes, alloxan was administered again to induce diabetes. The composition of the groups is shown in Table 1, and the following groups were used: Compulsory oral administration of human Candida albicans (6×10 7 individuals / mL) group (AC group, 15 rats), the group (A group, 14 rats) that did not administer human Candida albicans orally after the induction of diabetes, and did not administer alloxan only for compulsory oral administration of human Candida albicans Orally administered group (group C, 10 rats). In group AC, within 2 weeks after administ...

Embodiment 2

[0076] According to the results of Example 1, administration of human Candida albicans to alloxan-induced diabetic rats induces proliferative and inflammatory lesions in the forestomach, leading to canceration.

[0077] After fermenting with a starter based on a mixed starter of Lactobacillus bulgaricus and Streptococcus thermophilus standardized as a yogurt starter according to the CODEX standard, Lactobacillus gasseri OLL2716 was added and fermented, and the fermentation of the present invention obtained above was used. To investigate whether the proliferative and inflammatory lesions of the forestomach induced by human Candida albicans infection are inhibited.

[0078] The fermented product of the present invention is prepared in the following manner. First, Lactobacillus gasseri OLL2716 strain, Lactobacillus delbrueckii subsp. Bulgaricus (L.delbrueckii subsp.Bulgaricus) JCM1002 T Streptococcus thermophilus ATCC19258 was inoculated in 10% skimmed milk powder culture medium...

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Abstract

Provided are: a fermented material which is effective for the prevention of squamous carcinoma that is developed by Candida infection; a model animal for squamous carcinoma that is developed by Candida infection, in which the difference among individuals is smaller than those in conventional model animals and pharmacological efficacy can be evaluated more properly; and a method for producing the model animal. A prophylactic agent for squamous carcinoma that is developed by Candida infection, which comprises a fermented material produced by fermenting milk with L. bulgaricus, S. thermophilus and L. gasseri as an active ingredient.

Description

technical field [0001] The present invention relates to a preventive agent for squamous cell carcinoma caused by Candida infection, a method for producing a squamous cell carcinoma model animal, the squamous cell carcinoma model animal, and a screening method using the squamous cell carcinoma model animal. Background technique [0002] Oral cavity cancer and esophageal cancer are cancers derived from stratified squamous epithelium, and esophageal cancer in particular is a refractory cancer with a high mortality rate. On the other hand, it is known that human Candida albicans (C.albicans) is a common bacterium detected in the oral cavity of healthy people, but it is immune in patients after organ transplantation or major surgery, liver cirrhosis or diabetes. In patients with functional decline, severe oral candidiasis and esophageal candidiasis often occur. In addition, as the number of bedridden elderly people increases, they fall into a state of undernutrition, and the cha...

Claims

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Application Information

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IPC IPC(8): A23C9/12A01K67/027A23C9/127A23L1/00A23L1/30A61K35/74A61P35/00G01N33/15G01N33/50
CPCA23V2200/00A23Y2240/75A61K35/74A23L1/3014A23Y2220/37G01N33/50A01K67/027A23Y2220/15A23C9/1238A23L33/135A23V2002/00A61P35/00A23V2400/145A23V2400/123A23V2400/249A23V2200/308
Inventor 尾崎清和内田胜幸松浦哲郎
Owner MEIJI CO LTD
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