FePt/GO nanocomposite based diagnosis and treatment reagent and application thereof

Abstract

The invention discloses synthesis and an application of a FePt / GO nanocomposite based diagnosis and treatment reagent. A nano FePt / GO composite is taken as the core, and fluorescein isothiocyanate (FITC) and folic acid are connected by polyethylene glycol (PEG). Based on the design, the invention constructs a diagnosis and treatment nano probe which integrates multi-target (molecular level and external magnetic field), bimodal imaging diagnosis (MRI and fluorescence) and dual treatment (chemotherapy and thermal therapy) to treat the selected tumor, thereby achieving the central goal of early target diagnosis and synchronous in situ treatment of tumors. According to the nano probe, the main synthesis manner comprises low temperature microwave radiation-liquid phase synthesis, and graphene is taken as a carrier to control the synthesis of the FePt / GO nanocomposite. The core relates to controlled synthesis of FePt / GO nanocomposite, physicochemical property research, surface finish, target bimodal imaging in cellular level (invitro) and synchronous in situ treatment bimodule imaging location, and visualization treatment and curative effect evaluation.

Description

technical field [0001] The invention belongs to the field of pharmacy and nanomaterials, and in particular relates to the synthesis and application of a diagnosis and treatment reagent based on FePt / GO nanocomposite material. Background technique [0002] At present, the common clinical treatment methods for malignant tumors include: chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy, and gene therapy, etc., but there are still many problems in the existing treatment methods, such as single therapy, poor stability, and poor targeting , the body is prone to drug resistance, strong side effects and so on. In traditional clinical applications, medical imaging and treatment of diseases are often two independent processes, and in practice, the time interval between these two processes is long, which may delay the best time for disease treatment. Therefore, an important challenge facing the current biomedical field is how to combine medical imaging and treatme...

AI Technical Summary

Problems solved by technology

However, current chemotherapy has encountered many challenges, such as poor targeted delivery, strong side effects, and drug resistance of tumor cells, making it difficult to achieve the expected therapeutic effect.

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